Boc-NH-PEG6-CH2COOH

Modify Date: 2024-01-02 16:50:13

Boc-NH-PEG6-CH2COOH Structure
Boc-NH-PEG6-CH2COOH structure
Common Name Boc-NH-PEG6-CH2COOH
CAS Number 391684-36-9 Molecular Weight 439.498
Density 1.1±0.1 g/cm3 Boiling Point 557.7±50.0 °C at 760 mmHg
Molecular Formula C19H37NO10 Melting Point N/A
MSDS N/A Flash Point 291.1±30.1 °C

 Use of Boc-NH-PEG6-CH2COOH


Boc-NH-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid
Synonym More Synonyms

 Boc-NH-PEG6-CH2COOH Biological Activity

Description Boc-NH-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 557.7±50.0 °C at 760 mmHg
Molecular Formula C19H37NO10
Molecular Weight 439.498
Flash Point 291.1±30.1 °C
Exact Mass 439.241760
LogP -1.24
Vapour Pressure 0.0±3.3 mmHg at 25°C
Index of Refraction 1.467

 Synonyms

2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid
3,8,11,14,17,20,23-Heptaoxa-5-azapentacosan-25-oic acid, 2,2-dimethyl-4-oxo-