PF-03049423
Modify Date: 2024-01-14 17:59:12
PF-03049423 structure
|
Common Name | PF-03049423 | ||
|---|---|---|---|---|
| CAS Number | 402955-58-2 | Molecular Weight | 505.010 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H32N6O4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of PF-03049423PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM; displays 158-fold and 2460-fold selectivity over PDE6 and PDE11, respectively; possesses an excellent potency and selectivity profile and demonstrates robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model. Stroke Phase 2 Discontinued |
| Name | Pf-03049423 Hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM; displays 158-fold and 2460-fold selectivity over PDE6 and PDE11, respectively; possesses an excellent potency and selectivity profile and demonstrates robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model. Stroke Phase 2 Discontinued |
|---|---|
| References | References 1. Hughes RO, et al. J Med Chem. 2010 Mar 25;53(6):2656-60. 2. Di Cesare F, et al. J Stroke Cerebrovasc Dis. 2016 Mar;25(3):642-9. View Related Products by Target Phosphodiesterase (PDE) Stroke |
| Molecular Formula | C24H32N6O4 |
|---|---|
| Molecular Weight | 505.010 |
| Exact Mass | 504.225189 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| Pf-03049423 Hydrochloride |
| 3-[4-(2-Hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one hydrochloride (1:1) |
| Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)-, hydrochloride (1:1) |