DOCK2-IN-1
Modify Date: 2024-04-06 07:30:56
DOCK2-IN-1 structure
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Common Name | DOCK2-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 4590-86-7 | Molecular Weight | 298.72 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H11ClN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DOCK2-IN-1DOCK2-IN-1 (compound 3), a CPYPP (HY-110100) analogue, is an inhibitor of DOCK2 as well (IC50=19.1 μM). DOCK2-IN-1 binds to DOCK2 DHR-2 domain in a reversible manner to inhibits its catalytic activity. DOCK2-IN-1 blocks the activation of both chemokine receptor- and antigen receptor-mediated Rac in lymphocytes. DOCK2-IN-1 significantly suppresses chemotactic response and T cell activation[1]. |
| Name | DOCK2-IN-1 |
|---|
| Description | DOCK2-IN-1 (compound 3), a CPYPP (HY-110100) analogue, is an inhibitor of DOCK2 as well (IC50=19.1 μM). DOCK2-IN-1 binds to DOCK2 DHR-2 domain in a reversible manner to inhibits its catalytic activity. DOCK2-IN-1 blocks the activation of both chemokine receptor- and antigen receptor-mediated Rac in lymphocytes. DOCK2-IN-1 significantly suppresses chemotactic response and T cell activation[1]. |
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| Related Catalog | |
| Target |
DOCK2 |
| References |
| Molecular Formula | C16H11ClN2O2 |
|---|---|
| Molecular Weight | 298.72 |
| InChIKey | VEBASGXAFMQOLL-JLHYYAGUSA-N |
| SMILES | O=C1NN(c2ccccc2)C(=O)C1=Cc1ccccc1Cl |