Tangeretin

Modify Date: 2025-08-20 13:37:00

Tangeretin structure	Common Name	Tangeretin
	CAS Number	481-53-8	Molecular Weight	372.369
	Density	1.2±0.1 g/cm3	Boiling Point	565.3±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₀O₇	Melting Point	155 °C
	MSDS	Chinese USA	Flash Point	248.4±30.2 °C
	Symbol	GHS06	Signal Word	Danger

Use of Tangeretin

Tangeretin, a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor.IC50 value:Target: Notch-1In vitro: Tangeretin enhanced the radiosensitivity of GC cells as demonstrated by MTT and colony formation assays. Tangeretin also attenuated radiation-induced EMT, invasion and migration in GC cells, accompanied by a decrease in Notch-1, Jagged1/2, Hey-1 and Hes-1 expressions. Tangeretin triggered the upregulation of miR-410, a tumor-suppressive microRNA. Furthermore, re-expression of miR-410 prevented radiation-induced EMT and cell invasion [1]. In vivo: In this study, we investigated the in vivo anti-RSV activity of tangeretin in 3-week-old male BALB/c mice. A plaque reduction assay and fluorescence quantitative polymerase chain reaction (FQ-PCR) showed that tangeretin inhibited RSV replication in the lung of mice [2].

Name	tangeretin
Synonym	More Synonyms

Description	Tangeretin, a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor.IC50 value:Target: Notch-1In vitro: Tangeretin enhanced the radiosensitivity of GC cells as demonstrated by MTT and colony formation assays. Tangeretin also attenuated radiation-induced EMT, invasion and migration in GC cells, accompanied by a decrease in Notch-1, Jagged1/2, Hey-1 and Hes-1 expressions. Tangeretin triggered the upregulation of miR-410, a tumor-suppressive microRNA. Furthermore, re-expression of miR-410 prevented radiation-induced EMT and cell invasion [1]. In vivo: In this study, we investigated the in vivo anti-RSV activity of tangeretin in 3-week-old male BALB/c mice. A plaque reduction assay and fluorescence quantitative polymerase chain reaction (FQ-PCR) showed that tangeretin inhibited RSV replication in the lung of mice [2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Notch Research Areas >> Inflammation/Immunology Natural Products >> Flavonoids
References	[1]. Zhang X, et al. Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells. Oncol Rep. 2015 Jul;34(1):302-10. [2]. Xu JJ, et al. Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and Associated Inflammation in Vivo. J Agric Food Chem. 2015 Nov 4;63(43):9520-7. [3]. Hagenlocher Y, et al. Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS- and IgE-mediated activation of human intestinal mast cells. Eur J Nutr. 2016 Mar 28.

Description

Related Catalog

Signaling Pathways >> Stem Cell/Wnt >> Notch

Research Areas >> Inflammation/Immunology

Natural Products >> Flavonoids

References

[1]. Zhang X, et al. Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells. Oncol Rep. 2015 Jul;34(1):302-10.

[2]. Xu JJ, et al. Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and Associated Inflammation in Vivo. J Agric Food Chem. 2015 Nov 4;63(43):9520-7.

[3]. Hagenlocher Y, et al. Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS- and IgE-mediated activation of human intestinal mast cells. Eur J Nutr. 2016 Mar 28.

Density	1.2±0.1 g/cm3
Boiling Point	565.3±50.0 °C at 760 mmHg
Melting Point	155 °C
Molecular Formula	C₂₀H₂₀O₇
Molecular Weight	372.369
Flash Point	248.4±30.2 °C
Exact Mass	372.120911
PSA	76.36000
LogP	2.66
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.566
Water Solubility	insoluble

Tangeretin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3102725

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2-(4-methoxyphenyl)-5,6,7,8-tetramethoxy-

CAS REGISTRY NUMBER :: 481-53-8

BEILSTEIN REFERENCE NO. :: 0351695

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H20-O7

MOLECULAR WEIGHT :: 372.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 3,181,1968

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300
Precautionary Statements	P264-P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R25
Safety Phrases	S45
RIDADR	UN 2811
RTECS	DJ3102725
Hazard Class	6.1

Precursor 8
CAS#:74-88-4 methyl iodide CAS#:2798-22-3 5,8-dihydroxy-6... CAS#:77-78-1 Dimethyl sulfate CAS#:3162-28-5 1-(2-hydroxy-3,...
CAS#:4397-53-9 4-(Benzyloxy)be... CAS#:40110-95-0 1-(2-hydroxy-3,... CAS#:73898-14-3 4'-benzyloxy-5,... CAS#:19103-54-9 Salvigenin
DownStream 8
CAS#:2798-20-1 Gardenin B CAS#:19103-54-9 Salvigenin CAS#:21763-80-4 5-Demethylsinensetin CAS#:479-90-3 Artemetin
CAS#:2174-59-6 5-O-Demethylnob... CAS#:1176-88-1 5-OH-HxMF CAS#:6959-55-3 4H-1-Benzopyran... CAS#:577-26-4 5,6,7,8-tetrahy...

Phytochemical profile and antioxidant activity of physiological drop of citrus fruits.

J. Food Sci. 78(1) , C37-42, (2013)

The phytochemical content and the antioxidant activity (AA) of physiological drop of the main citrus species grown in China were investigated. Among the flavonoids, hesperidin was found mostly in mand...

Polymethoxylated flavones potentiate the cytolytic activity of NK leukemia cell line KHYG-1 via enhanced expression of granzyme B.

Biochem. Biophys. Res. Commun. 456(3) , 799-803, (2015)

Polymethoxylated flavones (PMFs) are found in the peel tissues of some citrus species. Here, we report that PMFs, such as nobiletin, potentiate the cytolytic activity of KHYG-1 natural killer (NK) leu...

Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice.

Mol. Cell. Endocrinol. 358(1) , 127-34, (2012)

Although the flavonoid tangeretin (5, 6, 7, 8, 4'-pentamethoxyflavone) is known to possess beneficial health effects, the anti-diabetic effects and the mechanism of action have not been elucidated. Tr...

4H-1-Benzopyran-4-one, 2-(4-methoxyphenyl)-5,6,7,8-tetramethoxy-

Ponkanetin

4',5,6,7,8-pentamethoxyflavone

4H-1-Benzopyran-4-one, 5,6,7,8-tetra-methoxy-2-(4-methoxyphenyl)-

Flavone, 5,6,7,8,4'-pentamethoxy

Flavone, 4',5,6,7,8-pentamethoxy-

TANGERETIN,NATURAL

MFCD00017438

4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-(p-methoxyphenyl)-

5,6,7,8,4'-Pentamethoxyflavone

4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-

5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

TANGARETIN

Tangeritin

Tangeritine

EINECS 207-570-1

Tangeretin

5-18-05-00491 (Beilstein Handbook Reference)

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tangeretin
Price: Check
Purity: 98.0%
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China
Product Name: Tangeretin
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Tangeretin
Price: ￥298.0/20mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Tangeretin
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tangeretin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: Tangeretin
Price: ￥Inquiry/100mg ￥Inquiry/10mg ￥Inquiry/1g ￥Inquiry/250mg
Purity: 98.0%
Delivery: Inquiry
Contact: Xiyao Wang
Email: 3623107365@qq.com

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Tangeretin

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Tangeretin Biological Activity

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MSDS

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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Precursor & DownStream

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