Tangeretin structure
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Common Name | Tangeretin | ||
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CAS Number | 481-53-8 | Molecular Weight | 372.369 | |
Density | 1.2±0.1 g/cm3 | Boiling Point | 565.3±50.0 °C at 760 mmHg | |
Molecular Formula | C20H20O7 | Melting Point | 155 °C | |
MSDS | Chinese USA | Flash Point | 248.4±30.2 °C | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of TangeretinTangeretin, a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor.IC50 value:Target: Notch-1In vitro: Tangeretin enhanced the radiosensitivity of GC cells as demonstrated by MTT and colony formation assays. Tangeretin also attenuated radiation-induced EMT, invasion and migration in GC cells, accompanied by a decrease in Notch-1, Jagged1/2, Hey-1 and Hes-1 expressions. Tangeretin triggered the upregulation of miR-410, a tumor-suppressive microRNA. Furthermore, re-expression of miR-410 prevented radiation-induced EMT and cell invasion [1]. In vivo: In this study, we investigated the in vivo anti-RSV activity of tangeretin in 3-week-old male BALB/c mice. A plaque reduction assay and fluorescence quantitative polymerase chain reaction (FQ-PCR) showed that tangeretin inhibited RSV replication in the lung of mice [2]. |
Name | tangeretin |
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Synonym | More Synonyms |
Description | Tangeretin, a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor.IC50 value:Target: Notch-1In vitro: Tangeretin enhanced the radiosensitivity of GC cells as demonstrated by MTT and colony formation assays. Tangeretin also attenuated radiation-induced EMT, invasion and migration in GC cells, accompanied by a decrease in Notch-1, Jagged1/2, Hey-1 and Hes-1 expressions. Tangeretin triggered the upregulation of miR-410, a tumor-suppressive microRNA. Furthermore, re-expression of miR-410 prevented radiation-induced EMT and cell invasion [1]. In vivo: In this study, we investigated the in vivo anti-RSV activity of tangeretin in 3-week-old male BALB/c mice. A plaque reduction assay and fluorescence quantitative polymerase chain reaction (FQ-PCR) showed that tangeretin inhibited RSV replication in the lung of mice [2]. |
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Related Catalog | |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 565.3±50.0 °C at 760 mmHg |
Melting Point | 155 °C |
Molecular Formula | C20H20O7 |
Molecular Weight | 372.369 |
Flash Point | 248.4±30.2 °C |
Exact Mass | 372.120911 |
PSA | 76.36000 |
LogP | 2.66 |
Vapour Pressure | 0.0±1.5 mmHg at 25°C |
Index of Refraction | 1.566 |
Water Solubility | insoluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H300 |
Precautionary Statements | P264-P301 + P310 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T:Toxic; |
Risk Phrases | R25 |
Safety Phrases | S45 |
RIDADR | UN 2811 |
RTECS | DJ3102725 |
Hazard Class | 6.1 |
Precursor 8 | |
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DownStream 8 | |
Phytochemical profile and antioxidant activity of physiological drop of citrus fruits.
J. Food Sci. 78(1) , C37-42, (2013) The phytochemical content and the antioxidant activity (AA) of physiological drop of the main citrus species grown in China were investigated. Among the flavonoids, hesperidin was found mostly in mand... |
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Polymethoxylated flavones potentiate the cytolytic activity of NK leukemia cell line KHYG-1 via enhanced expression of granzyme B.
Biochem. Biophys. Res. Commun. 456(3) , 799-803, (2015) Polymethoxylated flavones (PMFs) are found in the peel tissues of some citrus species. Here, we report that PMFs, such as nobiletin, potentiate the cytolytic activity of KHYG-1 natural killer (NK) leu... |
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Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice.
Mol. Cell. Endocrinol. 358(1) , 127-34, (2012) Although the flavonoid tangeretin (5, 6, 7, 8, 4'-pentamethoxyflavone) is known to possess beneficial health effects, the anti-diabetic effects and the mechanism of action have not been elucidated. Tr... |
4H-1-Benzopyran-4-one, 2-(4-methoxyphenyl)-5,6,7,8-tetramethoxy- |
Ponkanetin |
4',5,6,7,8-pentamethoxyflavone |
4H-1-Benzopyran-4-one, 5,6,7,8-tetra-methoxy-2-(4-methoxyphenyl)- |
Flavone, 5,6,7,8,4'-pentamethoxy |
Flavone, 4',5,6,7,8-pentamethoxy- |
TANGERETIN,NATURAL |
MFCD00017438 |
4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-(p-methoxyphenyl)- |
5,6,7,8,4'-Pentamethoxyflavone |
4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)- |
5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one |
TANGARETIN |
Tangeritin |
Tangeritine |
EINECS 207-570-1 |
Tangeretin |
5-18-05-00491 (Beilstein Handbook Reference) |