Harmane

Modify Date: 2024-01-08 10:42:42

Harmane structure	Common Name	Harmane
	CAS Number	486-84-0	Molecular Weight	182.221
	Density	1.3±0.1 g/cm3	Boiling Point	386.9±22.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₀N₂	Melting Point	235-238 °C(lit.)
	MSDS	Chinese USA	Flash Point	176.2±13.6 °C

Use of Harmane

Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect[1][2][3][4].

Name	harman
Synonym	More Synonyms

Description	Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect[1][2][3][4].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Imidazoline Receptor Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Imidazoline Receptor Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	hMAO-A:0.5 μM (IC50) MAO-B:5 μM (IC50) α2-adrenergic receptor:18 μM (IC50) I1-Imidazoline receptor:30 nM (IC50)
References	[1]. Louis ED, et, al. Blood harmane concentrations and dietary protein consumption in essential tremor. Neurology. 2005 Aug 9;65(3):391-6. [2]. Musgrave IF, et, al. Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors. Br J Pharmacol. 2000 Mar;129(6):1057-9. [3]. Glover V, et, al. β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications [4]. Umezawa K, et, al. Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives. Proc Natl Acad Sci U S A. 1978 Feb;75(2):928-30.

Density	1.3±0.1 g/cm3
Boiling Point	386.9±22.0 °C at 760 mmHg
Melting Point	235-238 °C(lit.)
Molecular Formula	C₁₂H₁₀N₂
Molecular Weight	182.221
Flash Point	176.2±13.6 °C
Exact Mass	182.084396
PSA	28.68000
LogP	3.26
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.750

Harmane MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV0280000

CHEMICAL NAME :: 9H-Pyrido(3,4-b)indole, 1-methyl-

CAS REGISTRY NUMBER :: 486-84-0

BEILSTEIN REFERENCE NO. :: 0143898

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C12-H10-N2

MOLECULAR WEIGHT :: 182.24

WISWESSER LINE NOTATION :: T B656 EN HMJ F

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: DNA adduct

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 100 mg/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 17,249,1983

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	20/21
Safety Phrases	S22-S24/25
RIDADR	1544
WGK Germany	3
RTECS	UV0280000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

Precursor 9
CAS#:525-41-7 Harmalane CAS#:5159-20-6 1-methyl-2-(tol... CAS#:2506-10-7 1H-Pyrido[3,4-b... CAS#:75-91-2 tert-Butyl Hydr...
CAS#:244-63-3 Norharmane CAS#:1016-47-3 N-Acetyltryptamine CAS#:127-19-5 N,N-Dimethylace... CAS#:82980-12-9 3-ethenyl-1-phe...
CAS#:5470-37-1 1H-Pyrido[3,4-b...
DownStream 10
CAS#:15071-56-4 5-Methoxycanthinone CAS#:244-63-3 Norharmane CAS#:139332-12-0 2,3-diethyl-12H... CAS#:102206-91-7 1-methyl-9H-pyr...
CAS#:102207-02-3 1-methyl-8-nitr... CAS#:38314-91-9 1-methyl-6-nitr... CAS#:138428-34-9 methyl 2-(9H-py... CAS#:20127-63-3 1-Formyl-beta-c...
CAS#:18813-71-3 9H-Pyrido[3,4-b... CAS#:2521-07-5 9-Methyl-9H-bet...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Harmane
Price: Click To Check
Purity: 95.0%
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China
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China
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DC Chemicals Limited
China
Product Name: Harman
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
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