4-Nitroquinoline 1-oxide

Modify Date: 2025-08-27 22:38:05

4-Nitroquinoline 1-oxide structure	Common Name	4-Nitroquinoline 1-oxide
	CAS Number	56-57-5	Molecular Weight	190.16
	Density	1.4±0.1 g/cm3	Boiling Point	387.6±34.0 °C at 760 mmHg
	Molecular Formula	C₉H₆N₂O₃	Melting Point	154-156 °C(lit.)
	MSDS	Chinese USA	Flash Point	188.2±25.7 °C
	Symbol	GHS08	Signal Word	Danger

Use of 4-Nitroquinoline 1-oxide

Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway[1][2].

Name	4-nitroquinoline N-oxide
Synonym	More Synonyms

Description	Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Mukherjee A, et al. Carcinogen 4-Nitroquinoline Oxide (4-NQO) Induces Oncostatin-M (OSM) in Esophageal Cells. In Vivo. 2023 Mar-Apr;37(2):506-518. [2]. Han H, et al. 4-NQO induces apoptosis via p53-dependent mitochondrial signaling pathway. Toxicology. 2007 Feb 12;230(2-3):151-63.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

References

[1]. Mukherjee A, et al. Carcinogen 4-Nitroquinoline Oxide (4-NQO) Induces Oncostatin-M (OSM) in Esophageal Cells. In Vivo. 2023 Mar-Apr;37(2):506-518.

[2]. Han H, et al. 4-NQO induces apoptosis via p53-dependent mitochondrial signaling pathway. Toxicology. 2007 Feb 12;230(2-3):151-63.

Density	1.4±0.1 g/cm3
Boiling Point	387.6±34.0 °C at 760 mmHg
Melting Point	154-156 °C(lit.)
Molecular Formula	C₉H₆N₂O₃
Molecular Weight	190.16
Flash Point	188.2±25.7 °C
Exact Mass	190.037842
PSA	71.28000
LogP	0.92
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.659
Storage condition	−20°C
Stability	Stable. Hygroscopic, light-sensitive. Incompatible with strong oxidizing agents.
Water Solubility	acetone: clear to hazy

4-Nitroquinoline 1-oxide MSDS(Chinese)

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H350
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	Xn:Harmful;
Risk Phrases	R33
Safety Phrases	S53-S45
RIDADR	2811
WGK Germany	3
RTECS	VC2100000
Packaging Group	II
Hazard Class	6.1

Precursor 4
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DownStream 10
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CAS#:20151-40-0 2,4-Dibromoquinoline CAS#:3741-15-9 4-Nitroquinoline

Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.

J. Mol. Biol. 426(24) , 4049-60, (2014)

Rad23 was identified as a DNA repair protein, although a role in protein degradation has been described. The protein degradation function of Rad23 contributes to cell cycle progression, stress respons...

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.

J. Cell Biol. 206(2) , 183-97, (2014)

Deoxyribonucleic acid (DNA) lesions encountered during replication are often bypassed using DNA damage tolerance (DDT) pathways to avoid prolonged fork stalling and allow for completion of DNA replica...

Genotoxicity testing of esterified propoxylated glycerol (EPG).

Regul Toxicol Pharmacol 70 Suppl 2 , S131-42, (2014)

Four versions of esterified propoxylated glycerols (EPGs) were evaluated for potential genotoxicity using a range of in vitro and in vivo assays. H-EPG-05 HR/SO 9:1, H-EPG-05 soyate, and H-EPG-14 soya...

EINECS 200-281-1

MFCD00006738

4-nitro-1-oxidoquinolin-1-ium

4-nitroquinoline-N-oxide

Quinoline, 4-nitro-, 1-oxide

4-Nitroquinoline 1-oxide

4-nitroquinoline n-oxide

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Nitroquinoline 1-oxide
Price: Check
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China
Product Name: 4-Nitroquinoline 1-oxide
Price: ￥218.0/250mg ￥638.0/1g
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: 4-Nitroquinoline 1-oxide
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Nitroquinoline N-oxide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥500/100 mg

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4-Nitroquinoline 1-oxide

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4-Nitroquinoline 1-oxide Biological Activity

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