4-Nitroquinoline 1-oxide

Modify Date: 2026-07-16 15:20:21

4-Nitroquinoline 1-oxide structure	Common Name	4-Nitroquinoline 1-oxide
	CAS Number	56-57-5	Molecular Weight	190.16
	Density	1.4±0.1 g/cm3	Boiling Point	387.6±34.0 °C at 760 mmHg
	Molecular Formula	C₉H₆N₂O₃	Melting Point	154-156 °C(lit.)
	MSDS	Chinese USA	Flash Point	188.2±25.7 °C
	Symbol	GHS08	Signal Word	Danger

Use of 4-Nitroquinoline 1-oxide

Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	4-nitroquinoline N-oxide
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Mukherjee A, et al. Carcinogen 4-Nitroquinoline Oxide (4-NQO) Induces Oncostatin-M (OSM) in Esophageal Cells. In Vivo. 2023 Mar-Apr;37(2):506-518. [2]. Han H, et al. 4-NQO induces apoptosis via p53-dependent mitochondrial signaling pathway. Toxicology. 2007 Feb 12;230(2-3):151-63.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

References

[1]. Mukherjee A, et al. Carcinogen 4-Nitroquinoline Oxide (4-NQO) Induces Oncostatin-M (OSM) in Esophageal Cells. In Vivo. 2023 Mar-Apr;37(2):506-518.

[2]. Han H, et al. 4-NQO induces apoptosis via p53-dependent mitochondrial signaling pathway. Toxicology. 2007 Feb 12;230(2-3):151-63.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.4±0.1 g/cm3
Boiling Point	387.6±34.0 °C at 760 mmHg
Melting Point	154-156 °C(lit.)
Molecular Formula	C₉H₆N₂O₃
Molecular Weight	190.16
Flash Point	188.2±25.7 °C
Exact Mass	190.037842
PSA	71.28000
LogP	0.92
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.659
InChIKey	YHQDZJICGQWFHK-UHFFFAOYSA-N
SMILES	O=[N+]([O-])c1cc[n+]([O-])c2ccccc12
Storage condition	−20°C
Stability	Stable. Hygroscopic, light-sensitive. Incompatible with strong oxidizing agents.
Water Solubility	acetone: clear to hazy

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

4-Nitroquinoline 1-oxide MSDS(Chinese)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H350
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	Xn:Harmful;
Risk Phrases	R33
Safety Phrases	S53-S45
RIDADR	2811
WGK Germany	3
RTECS	VC2100000
Packaging Group	II
Hazard Class	6.1

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 4
CAS#:1613-37-2 quinoline 1-oxide CAS#:3741-15-9 4-Nitroquinoline CAS#:120309-60-6 CAS#:7664-93-9 Sulfuric acid
DownStream 10
CAS#:39061-97-7 4-Chloro-3-nitr... CAS#:607-31-8 4-Methoxyquinoline CAS#:4552-43-6 4-chloroquinoli... CAS#:36825-36-2 3-Bromo-4-quino...
CAS#:486-74-8 4-Quinolinecarb... CAS#:4637-56-3 4-Hydroxyaminoq... CAS#:18061-48-8 1-acetoxy-4-ace... CAS#:20146-63-8 2-Bromo-4-nitro...
CAS#:20151-40-0 2,4-Dibromoquinoline CAS#:3741-15-9 4-Nitroquinoline

This table lists relevant public references with title, journal and publication metadata for this compound.

Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.

J. Mol. Biol. 426(24) , 4049-60, (2014)

Rad23 was identified as a DNA repair protein, although a role in protein degradation has been described. The protein degradation function of Rad23 contributes to cell cycle progression, stress respons...

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.

J. Cell Biol. 206(2) , 183-97, (2014)

Deoxyribonucleic acid (DNA) lesions encountered during replication are often bypassed using DNA damage tolerance (DDT) pathways to avoid prolonged fork stalling and allow for completion of DNA replica...

Genotoxicity testing of esterified propoxylated glycerol (EPG).

Regul Toxicol Pharmacol 70 Suppl 2 , S131-42, (2014)

Four versions of esterified propoxylated glycerols (EPGs) were evaluated for potential genotoxicity using a range of in vitro and in vivo assays. H-EPG-05 HR/SO 9:1, H-EPG-05 soyate, and H-EPG-14 soya...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Antifungal activity against yeast AD1-8u expressing Candida albicans CaCdr1p by agar ...
Source: ChEMBL
Target: Saccharomyces cerevisiae
External Id: CHEMBL1285395

Name: Mutagenicity in Salmonella typhimurium TA98 assessed as fold increase in number of po...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4433291

Name: Mutagenicity in Salmonella typhimurium TA100 assessed as fold increase in number of p...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4433292

Name: Binding affinity to Candida albicans CaCdr1p expressed in yeast AD1-8u
Source: ChEMBL
Target: N/A
External Id: CHEMBL1285392

Name: Antifungal activity against yeast AD1-8u expressing Candida albicans CaMdr1p by agar ...
Source: ChEMBL
Target: Saccharomyces cerevisiae
External Id: CHEMBL1285393

Name: Binding affinity to Candida albicans CaMdr1p expressed in yeast AD1-8u
Source: ChEMBL
Target: N/A
External Id: CHEMBL1285394

Name: Mutagenicity in Vibrio harveyi BB7XM assessed as number of colonies at 40 ng/ml after...
Source: ChEMBL
Target: Vibrio harveyi
External Id: CHEMBL3777278

Name: Mutagenicity in Vibrio harveyi BB7M assessed as number of colonies at 40 ng/ml after ...
Source: ChEMBL
Target: Vibrio harveyi
External Id: CHEMBL3777277

Name: Mutagenicity in Vibrio harveyi BB7X assessed as number of colonies at 40 ng/ml after ...
Source: ChEMBL
Target: Vibrio harveyi
External Id: CHEMBL3777276

Name: Cell survival assay for modulators of telomere damage signalling
Source: 15378
Target: N/A
External Id: TELO_02

Total 56, Current Page 1 of 6

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

EINECS 200-281-1

MFCD00006738

4-nitro-1-oxidoquinolin-1-ium

4-nitroquinoline-N-oxide

Quinoline, 4-nitro-, 1-oxide

4-Nitroquinoline 1-oxide

4-nitroquinoline n-oxide

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of 4-nitroquinoline N-oxide?

A: CAS number of 4-nitroquinoline N-oxide is 56-57-5.

Q: What are the storage conditions for 4-nitroquinoline N-oxide?

A: Storage conditions for 4-nitroquinoline N-oxide: −20°C.

Q: What are the downstream products of 4-nitroquinoline N-oxide?

A: Related downstream products(CAS) of 4-nitroquinoline N-oxide: 39061-97-7;607-31-8;4552-43-6;36825-36-2;486-74-8;4637-56-3;18061-48-8;20146-63-8;20151-40-0;3741-15-9.

Q: What is the LogP of 4-nitroquinoline N-oxide?

A: LogP of 4-nitroquinoline N-oxide is 0.92.

Q: What English synonyms does 4-nitroquinoline N-oxide have?

A: English synonyms of 4-nitroquinoline N-oxide: EINECS 200-281-1, MFCD00006738, 4-nitro-1-oxidoquinolin-1-ium, 4-nitroquinoline-N-oxide, Quinoline, 4-nitro-, 1-oxide, 4-Nitroquinoline 1-oxide, 4-nitroquinoline n-oxide.

Q: What are the uses of 4-nitroquinoline N-oxide?

A: Main uses of 4-nitroquinoline N-oxide: Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway[1][2].

Q: What is the InChIKey of 4-nitroquinoline N-oxide?

A: InChIKey of 4-nitroquinoline N-oxide is YHQDZJICGQWFHK-UHFFFAOYSA-N.

Q: What is the molecular formula of 4-nitroquinoline N-oxide?

A: Molecular formula of 4-nitroquinoline N-oxide is C9H6N2O3.

Q: What is the boiling point of 4-nitroquinoline N-oxide?

A: Boiling point of 4-nitroquinoline N-oxide is 387.6±34.0 °C at 760 mmHg.

Q: What is the melting point of 4-nitroquinoline N-oxide?

A: Melting point of 4-nitroquinoline N-oxide is 154-156 °C(lit.).

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Nitroquinoline 1-oxide
Price: Check
Purity: 99.87%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Nitroquinoline N-oxide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥500/100 mg

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