NSC 146109 (hydrochloride)

Modify Date: 2024-01-05 17:48:01

NSC 146109 (hydrochloride) Structure
NSC 146109 (hydrochloride) structure
Common Name NSC 146109 (hydrochloride)
CAS Number 59474-01-0 Molecular Weight 316.84800
Density 1.23g/cm3 Boiling Point 493.6ºC at 760 mmHg
Molecular Formula C17H17ClN2S Melting Point N/A
MSDS N/A Flash Point 252.3ºC

 Use of NSC 146109 (hydrochloride)


NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and could be of value in treating breast cancer.NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes[1].

 Names

Name (10-methylanthracen-9-yl)methyl carbamimidothioate
Synonym More Synonyms

 NSC 146109 (hydrochloride) Biological Activity

Description NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and could be of value in treating breast cancer.NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes[1].
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References

[1]. Wang H, et al. A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells. Neoplasia. 2011 Jul;13(7):611-9.

 Chemical & Physical Properties

Density 1.23g/cm3
Boiling Point 493.6ºC at 760 mmHg
Molecular Formula C17H17ClN2S
Molecular Weight 316.84800
Flash Point 252.3ºC
Exact Mass 316.08000
PSA 61.18000
LogP 5.98580
Index of Refraction 1.665

 Synonyms

10-Methyl-9-anthrylmethylisothioharnstoff Hydrochlorid
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