Xanthopterin Hydrate

Modify Date: 2024-01-11 20:08:32

Xanthopterin Hydrate Structure
Xanthopterin Hydrate structure
Common Name Xanthopterin Hydrate
CAS Number 5979-01-1 Molecular Weight 197.15100
Density N/A Boiling Point 458.7ºC at 760 mmHg
Molecular Formula C6H7N5O3 Melting Point >300 °C(lit.)
MSDS N/A Flash Point 231.2ºC

 Use of Xanthopterin Hydrate


Xanthopterin hydrate, an unconjugated pteridine compound, is the main component of the yellow granule in the Oriental hornet bear wings, produces a characteristic excitation/emission maximum at 386/456 nm[2]. Xanthopterin hydrate(XPT) causes renal growth and hypertrophy in rat[1].Xanthopterin hydrate inhibits RNA synthesis[4].

 Names

Name xanthopterin monohydrate
Synonym More Synonyms

 Xanthopterin Hydrate Biological Activity

Description Xanthopterin hydrate, an unconjugated pteridine compound, is the main component of the yellow granule in the Oriental hornet bear wings, produces a characteristic excitation/emission maximum at 386/456 nm[2]. Xanthopterin hydrate(XPT) causes renal growth and hypertrophy in rat[1].Xanthopterin hydrate inhibits RNA synthesis[4].
Related Catalog
In Vitro Xanthopterin (7.8-250 mM; 24 hours) show a significant reduction in mitochondrial activity with respect to controls (IC50=109 mM)[2]. Cell Viability Assay[2] Cell Line: MCF-7 cells Concentration: 7.8 mM-250 mM Incubation Time: 24 hours Result: Resulted in a reduction in mitochondrial activity.
References

[1]. Xanthopterin (XPT), an unconjugated pteridine compound, affects cell growth and differentiation. When injected into rats, XPT has caused changes that have been interpreted as renal growth and hypertrophy.

[2]. Lord JL, et al. Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells. Cancer Lett. 2005 May 10;222(1):119-24.

[3]. Plotkin M, et al. Xanthopterin in the Oriental hornet (Vespa orientalis): light absorbance is increased with maturation of yellow pigment granules. Photochem Photobiol. 2009 Jul-Aug;85(4):955-61.

[4]. Ziegler I, et al. Pterins and the regulation of lymphocyte activation on the mode of xanthopterin action. Hoppe Seylers Z Physiol Chem. 1984 Jun;365(6):667-73.

 Chemical & Physical Properties

Boiling Point 458.7ºC at 760 mmHg
Melting Point >300 °C(lit.)
Molecular Formula C6H7N5O3
Molecular Weight 197.15100
Flash Point 231.2ºC
Exact Mass 197.05500
PSA 127.27000

 Safety Information

Safety Phrases S22-S24/25
WGK Germany 3

 Synonyms

2-AMINO-4,6-PTERIDINEDIOL
2-aminopteridine-4,6-diol
XANTHOPTERIN(RG)
XANTHOPTERIN HYDRATE
2-Amino-4,6-pteridindiol
MFCD00151242
EINECS 204-325-0