Terazosin hydrochloride

Modify Date: 2025-08-23 16:24:21

Terazosin hydrochloride structure	Common Name	Terazosin hydrochloride
	CAS Number	63074-08-8	Molecular Weight	423.89
	Density	1.3±0.1 g/cm3	Boiling Point	664.5±65.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₆ClN₅O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	355.7±34.3 °C

Use of Terazosin hydrochloride

Terazosin hydrochloride is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment[1][2][3].

Name	Terazosin hydrochloride
Synonym	More Synonyms

Description	Terazosin hydrochloride is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment[1][2][3].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Metabolic Disease
Target	α1-adrenoceptor[1]
In Vitro	Terazosin does not discriminate cloned α1-adrenoceptor subtypes transiently expressed in COS cells[1].
In Vivo	Terazosin can be used to promote stone discharge in treatment of ureteral stones. Terazosin is reportedly safe and effective in treatment of distal ureteral stones, especially stones >5 mm[3].
References	[1]. Michel MC, et al. Drugs for treatment of benign prostatic hyperplasia: affinity comparison at cloned alpha 1-adrenoceptor subtypes and in human prostate. J Auton Pharmacol. 1996 Feb;16(1):21-8. [2]. Vincent J, et al. Pharmacological tolerance to alpha 1-adrenergic receptor antagonism mediated by terazosin in humans. J Clin Invest. 1992 Nov;90(5):1763-8. [3]. Ju M, et al. Efficacy of combination terazosin and nifedipine therapy in postoperative treatment of distal ureteral stones after transurethral ureteroscopic lithotripsy. J Int Med Res. 2020 Apr;48(4):300060520904851.

Density	1.3±0.1 g/cm3
Boiling Point	664.5±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₆ClN₅O₄
Molecular Weight	423.89
Flash Point	355.7±34.3 °C
PSA	103.04000
LogP	-0.96
Appearance of Characters	powder,white to off-white
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.636
Storage condition	Store at RT
Water Solubility	H2O: 25 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK8045000

CHEMICAL NAME :: Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahyd ro-2-furanyl)carbonyl )-, monohydrochloride

CAS REGISTRY NUMBER :: 63074-08-8

LAST UPDATED :: 199503

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H25-N5-O4.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 277 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 7,435,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4650 mg/kg/31D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Nutritional and Gross Metabolic - body temperature decrease Related to Chronic Data - death

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 7,435,1984

Hazard Codes	Xn,Xi
Risk Phrases	22-36/37/38
Safety Phrases	26-36
WGK Germany	3
RTECS	TK8044925

piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-

Terazosin

UNII:8L5014XET7

Vicard

Itrin

[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone,hydrochloride

Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-

Urodie

[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)methanone

6,7-bis(methyloxy)-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine

MFCD00467965

[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](tetrahydrofuran-2-yl)methanone

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Terazosin hydrochloride
Price: Check
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Terazosin hydrochloride
Price: ￥818.0/25g ￥288.0/5g ￥98.0/1g
Purity: 96.0%
Delivery: Inquiry
Contact: Liu jia
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Terazosin hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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