Xanthine oxidoreductase-IN-3

Modify Date: 2024-04-06 09:35:50

Xanthine oxidoreductase-IN-3 Structure
Xanthine oxidoreductase-IN-3 structure
Common Name Xanthine oxidoreductase-IN-3
CAS Number 651769-78-7 Molecular Weight 299.71500
Density N/A Boiling Point N/A
Molecular Formula C14H10ClN5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Xanthine oxidoreductase-IN-3


Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia[1].

 Names

Name N-(4-chlorophenyl)-4-(2H-tetrazol-5-yl)benzamide
Synonym More Synonyms

 Xanthine oxidoreductase-IN-3 Biological Activity

Description Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia[1].
Related Catalog
Target

IC50: 26.3 nM (xanthine oxidoreductase)[1]

In Vivo Xanthine oxidoreductase-IN-3 (化合物 IIIa) (5 mg/kg; 口服给药) 在给药后 3 h 显示出降低急性高尿酸血症小鼠尿酸的作用[1]。 Animal Model: ICR mice (18-22 g) were induced acute hyperuricemia by injection of potassium oxonate and hypoxanthine[1] Dosage: 5 mg/kg Administration: Suspended in 0.5% CMC-Na solution for intragastric administration Result: Showed a uric acid-lowering effect from 3 h after administration.
References

[1]. Peng W, et, al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947.  

 Chemical & Physical Properties

Molecular Formula C14H10ClN5O
Molecular Weight 299.71500
Exact Mass 299.05700
PSA 87.05000
LogP 3.15640

 Synonyms

Benzamide,N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)
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