MS 15203

Modify Date: 2024-01-03 12:50:53

MS 15203 Structure
MS 15203 structure
Common Name MS 15203
CAS Number 73912-52-4 Molecular Weight 249.21900
Density 1.42g/cm3 Boiling Point 561.3ºC at 760 mmHg
Molecular Formula C12H11NO5 Melting Point N/A
MSDS N/A Flash Point 293.2ºC

 Use of MS 15203


MS15203 is a potent and selective GPR171 agonist. MS15203 increases food intake and body weight. MS15203 increases neuronal activity. MS15203 significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP[1].

 Names

Name chembrdg-bb 5186719
Synonym More Synonyms

 MS 15203 Biological Activity

Description MS15203 is a potent and selective GPR171 agonist. MS15203 increases food intake and body weight. MS15203 increases neuronal activity. MS15203 significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP[1].
Related Catalog
In Vitro MS15203 (MS0015203) dose-dependently increases [[35]S]GTPγS binding and inhibits adenylyl cyclase activity in rat hypothalamic membranes[1].
In Vivo MS15203 (MS0015203) (3 mg/kg; i.p.) causes an increase in neuronal activity within cells containing GPR171 in the PVN[1]. .MS15203 (3 mg/kg; i.p.) significantly increases food intake at 4 and 8 hours[1]. MS15203 (3 mg/kg; i.p.) significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP[1].
References

[1]. Wardman JH, et al. Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Sci Signal. 2016 May 31;9(430):ra55.

 Chemical & Physical Properties

Density 1.42g/cm3
Boiling Point 561.3ºC at 760 mmHg
Molecular Formula C12H11NO5
Molecular Weight 249.21900
Flash Point 293.2ºC
Exact Mass 249.06400
PSA 103.70000
LogP 1.67060
Index of Refraction 1.639

 Safety Information

HS Code 2924199090

 Synthetic Route

~82%

MS 15203 Structure

MS 15203

CAS#:73912-52-4

Literature: Ezhova, N. M.; Kulina, E. A.; Kuznetsova, N. N. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980 , vol. 29, # 2 p. 267 - 269 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980 , # 2 p. 352 - 354

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

MFCD00434754
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