Ms-PEG4-t-butyl ester

Modify Date: 2024-01-03 09:26:22

Ms-PEG4-t-butyl ester Structure
Ms-PEG4-t-butyl ester structure
Common Name Ms-PEG4-t-butyl ester
CAS Number 870487-48-2 Molecular Weight 400.485
Density 1.1±0.1 g/cm3 Boiling Point 499.9±40.0 °C at 760 mmHg
Molecular Formula C16H32O9S Melting Point N/A
MSDS N/A Flash Point 256.1±27.3 °C

 Use of Ms-PEG4-t-butyl ester


Ms-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl 3,6,9,12,15-pentaoxa-2-thiaoctadecan-18-oate 2,2-dioxide
Synonym More Synonyms

 Ms-PEG4-t-butyl ester Biological Activity

Description Ms-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 499.9±40.0 °C at 760 mmHg
Molecular Formula C16H32O9S
Molecular Weight 400.485
Flash Point 256.1±27.3 °C
Exact Mass 400.176697
LogP -0.13
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.460

 Synonyms

MFCD20926382
2-Methyl-2-propanyl 3,6,9,12,15-pentaoxa-2-thiaoctadecan-18-oate 2,2-dioxide
3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-[(methylsulfonyl)oxy]-, 1,1-dimethylethyl ester
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