Propargyl-PEG4-alcohol
Propargyl-PEG4-alcohol structure
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Common Name | Propargyl-PEG4-alcohol | ||
|---|---|---|---|---|
| CAS Number | 87450-10-0 | Molecular Weight | 232.27300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H20O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Propargyl-PEG4-alcoholPropargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
| Name | 2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethanol |
|---|---|
| Synonym | More Synonyms |
| Description | Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1. |
| Molecular Formula | C11H20O5 |
|---|---|
| Molecular Weight | 232.27300 |
| Exact Mass | 232.13100 |
| PSA | 57.15000 |
| Hazard Codes | Xi |
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~82%
Propargyl-PEG4-... CAS#:87450-10-0 |
| Literature: Pinter, Gabor; Bereczki, Ilona; Roth, Elizabeth; Sipos, Attila; Varghese, Reny; Udo, Edet Ekpenyong; Ostorhazi, Eszter; Rozgonyi, Ferenc; Phillips, Oludotun Adebayo; Herczegh, Pal Medicinal Chemistry, 2011 , vol. 7, # 1 p. 45 - 55 |
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~58%
Propargyl-PEG4-... CAS#:87450-10-0 |
| Literature: SANOFI Patent: US2012/225089 A1, 2012 ; |
|
~82%
Propargyl-PEG4-... CAS#:87450-10-0 |
| Literature: Sung, Sae Reum; Han, Seung Choul; Jin, Sung-Ho; Lee, Jae Wook Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 11 p. 3933 - 3940 |
|
~56%
Propargyl-PEG4-... CAS#:87450-10-0 |
| Literature: Yin, Yanzhen; Huang, Xin; Lv, Chunyan; Wang, Liang; Yu, Shuangjiang; Luo, Quan; Xu, Jiayun; Liu, Junqiu Macromolecular Bioscience, 2010 , vol. 10, # 12 p. 1505 - 1516 |
|
~45%
Propargyl-PEG4-... CAS#:87450-10-0 |
| Literature: Serpell, Christopher J.; Chall, Ricky; Thompson, Amber L.; Beer, Paul D. Dalton Transactions, 2011 , vol. 40, # 45 p. 12052 - 12055 |
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~%
Propargyl-PEG4-... CAS#:87450-10-0 |
| Literature: Breyholz, Hans-Joerg; Wagner, Stefan; Faust, Andreas; Riemann, Burkhard; Hoeltke, Carsten; Hermann, Sven; Schober, Otmar; Schaefers, Michael; Kopka, Klaus ChemMedChem, 2010 , vol. 5, # 5 p. 777 - 789 |
![2-[2-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-6-methylpyran-4-ylidene]propanedinitrile structure](https://image.chemsrc.com/caspic/139/96042-30-7.png)
| 15-hydroxy-4,7,10,13-tetraoxapentadec-1-yne |
| 3,6,9,12-Tetraoxapentadec-14-yn-1-ol |
| 2-{2-[2-(2-proponyloxy-ethoxy)-ethoxy]-ethoxy}-ethanol |
| 2-{2-[2-(2-prop-2-ynyloxy-ethoxy)-ethoxy]-ethoxy}-ethanol |
| propargyl-PEG5 |
| tetraethylene glycol monopropargyl ether |