Broussonin E

Modify Date: 2024-01-10 08:50:04

Broussonin E structure	Common Name	Broussonin E
	CAS Number	90902-21-9	Molecular Weight	288.338
	Density	1.2±0.1 g/cm3	Boiling Point	464.9±40.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₂₀O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	235.0±27.3 °C

Use of Broussonin E

Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis[1].

Name	Broussonin E
Synonym	More Synonyms

Description	Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Immunology/Inflammation >> Arginase Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK p38 MAPK JAK2 STAT3 IL-1β IL-6 COX-2 IL-10
In Vitro	Broussonin E (20 μM, 3 h) 抑制 LPS (Lipopolysaccharides，HY-D1056) 刺激的磷酸化 ERK 和 p38 MAPK[1]。 Broussonin E 可激活 janus 激酶 (JAK) 2、信号转导和转录激活因子 (STAT) 3[1]。 Broussonin E (0-20 μM, 3 h) 可抑制 RAW264.7 细胞中 LPS 诱导的促炎产生，包括 TNF-α、IL-1β、IL-6、COX-2 和 iNOS[1 ]. Broussonin E 增强 LPS 刺激的 RAW264.7 细胞中抗炎介质如 IL-10、CD206 和精氨酸酶-1 (Arg-1) 的表达[1]。 Western Blot Analysis[1] Cell Line: RAW264.7 cells Concentration: 2.5, 5, 10 and 20 Incubation Time: 3 h Result: Inhibited p-ERK and p-p38 MAPK, but not p-JNK MAPK expression in LPS-stimulated RAW264.7 cells.
References	[1]. Huang SP, et al. Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway. Chin J Nat Med. 2019 May 20;17(5):372-380.

Density	1.2±0.1 g/cm3
Boiling Point	464.9±40.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₀O₄
Molecular Weight	288.338
Flash Point	235.0±27.3 °C
Exact Mass	288.136169
PSA	58.92000
LogP	3.35
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.586