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90902-21-9

90902-21-9 structure
90902-21-9 structure
  • Name: Broussonin E
  • Chemical Name: Broussonin E
  • CAS Number: 90902-21-9
  • Molecular Formula: C17H20O4
  • Molecular Weight: 288.338
  • Catalog: Natural product Phenols
  • Create Date: 2017-10-11 06:19:42
  • Modify Date: 2025-08-27 11:07:35
  • Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis[1].

Name Broussonin E
Synonyms Phenol, 5-[3-(2-hydroxy-4-methoxyphenyl)propyl]-2-methoxy-
5-[3-(2-Hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenol
Description Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis[1].
Related Catalog
Target

ERK

p38 MAPK

JAK2

STAT3

IL-1β

IL-6

COX-2

IL-10

In Vitro Broussonin E (20 μM, 3 h) 抑制 LPS (Lipopolysaccharides,HY-D1056) 刺激的磷酸化 ERK 和 p38 MAPK[1]。 Broussonin E 可激活 janus 激酶 (JAK) 2、信号转导和转录激活因子 (STAT) 3[1]。 Broussonin E (0-20 μM, 3 h) 可抑制 RAW264.7 细胞中 LPS 诱导的促炎产生,包括 TNF-α、IL-1β、IL-6、COX-2 和 iNOS[1 ]. Broussonin E 增强 LPS 刺激的 RAW264.7 细胞中抗炎介质如 IL-10、CD206 和精氨酸酶-1 (Arg-1) 的表达[1]。 Western Blot Analysis[1] Cell Line: RAW264.7 cells Concentration: 2.5, 5, 10 and 20 Incubation Time: 3 h Result: Inhibited p-ERK and p-p38 MAPK, but not p-JNK MAPK expression in LPS-stimulated RAW264.7 cells.
References

[1]. Huang SP, et al. Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway. Chin J Nat Med. 2019 May 20;17(5):372-380.  

Density 1.2±0.1 g/cm3
Boiling Point 464.9±40.0 °C at 760 mmHg
Molecular Formula C17H20O4
Molecular Weight 288.338
Flash Point 235.0±27.3 °C
Exact Mass 288.136169
PSA 58.92000
LogP 3.35
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.586
Hazard Codes Xi
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