4-Chlorobenzene-1,2-diamine

Modify Date: 2026-06-30 12:25:54

4-Chlorobenzene-1,2-diamine structure	Common Name	4-Chlorobenzene-1,2-diamine
	CAS Number	95-83-0	Molecular Weight	142.586
	Density	1.3±0.1 g/cm3	Boiling Point	300.2±22.0 °C at 760 mmHg
	Molecular Formula	C₆H₇ClN₂	Melting Point	70-73 °C(lit.)
	MSDS	Chinese USA	Flash Point	135.4±22.3 °C
	Symbol	GHS07, GHS08	Signal Word	Warning

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	4-Chloro-1,2-diaminobenzene
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.3±0.1 g/cm3
Boiling Point	300.2±22.0 °C at 760 mmHg
Melting Point	70-73 °C(lit.)
Molecular Formula	C₆H₇ClN₂
Molecular Weight	142.586
Flash Point	135.4±22.3 °C
Exact Mass	142.029770
PSA	52.04000
LogP	1.15
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.671
InChIKey	BXIXXXYDDJVHDL-UHFFFAOYSA-N
SMILES	Nc1ccc(Cl)cc1N
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	16 g/L (20 ºC)

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

4-Chlorobenzene-1,2-diamine MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SS8850000

CHEMICAL NAME :: o-Phenylenediamine, 4-chloro-

CAS REGISTRY NUMBER :: 95-83-0

BEILSTEIN REFERENCE NO. :: 0508472

LAST UPDATED :: 199710

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: C6-H7-Cl-N2

MOLECULAR WEIGHT :: 142.60

WISWESSER LINE NOTATION :: ZR BZ DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 135 gm/kg/77W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 324 gm/kg/77W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 273 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 917 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 136 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40500 gm/kg/96W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18750 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 14,207,1989 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,81,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,81,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H315-H319-H335-H351
Precautionary Statements	P261-P281-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn:Harmful;
Risk Phrases	R36/37/38;R40
Safety Phrases	S26-S36/37
RIDADR	2811
WGK Germany	3
RTECS	SS8850000
Packaging Group	I; II; III
Hazard Class	6.1
HS Code	2921590090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:89-63-4 4-Chloro-2-nitr... CAS#:1635-61-6 5-Chloro-2-nitr... CAS#:17348-69-5 2,1,3-Benzoxadi... CAS#:2207-32-1 5-Chlorobenzo-2...
CAS#:610-40-2 1-Chloro-3,4-di... CAS#:7440-66-6 Zinc CAS#:881-51-6 N-(4-Chloro-2-n... CAS#:106-47-8 4-Chloroaniline
CAS#:52184-29-9 (6E)-2,4-ditert... CAS#:5228-61-5 5-Bromo-2-nitro...
DownStream 10
CAS#:39811-14-8 6-CHLORO-1H-BEN... CAS#:5448-43-1 6-CHLOROQUINOXALINE CAS#:3584-66-5 1H-Benzimidazol... CAS#:14225-75-3 1H-Benzimidazol...
CAS#:144729-44-2 4-chloro-3-nitr... CAS#:14537-47-4 1H-Benzimidazol... CAS#:4887-82-5 5-Chloro-1H-ben... CAS#:2818-69-1 5-Chloro-2-meth...
CAS#:51-17-2 Benzimidazole CAS#:94-97-3 5-Chloro-1H-ben...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2921590090
Summary	2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.

Eur. J. Med. Chem. 44 , 3658-64, (2009)

A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above u...

4-Chloro-ortho-phenylenediamine and 4-chloro-meta-phenylenediamine.

IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 27 , 81-9, (1982)

Carcinogenicity of 4-chloro-o-phenylenediamine, 4-chloro-m-phenylenediamine, and 2-chloro-p-phenylenediamine in Fischer 344 rats and B6C3F1 mice.

Carcinogenesis 1(6) , 495-9, (1980)

In both male and female Fischer rats, feeding 4-chloro-o-phenylenediamine at 0.5 or 1% in the diet led to a significant increase in hyperplasia, papilloma and carcinoma of the urinary bladder. Neoplas...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Cell Viability Profiling of Human Lymphoblast Cell Lines
Source: NCGC
Target: N/A
External Id: HAPV101

Name: Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines
Source: NCGC
Target: N/A
External Id: HAPC101

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Total 275, Current Page 1 of 28

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

EINECS 202-456-8

4-Chloro-1,2-phenylenediamine

4-Chlorobenzene-1,2-diamine

4-Chloro-1,2-diaminobenzene

4-Chloro-1,2-benzenediamine

MFCD00011691

ZR BZ DG

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular weight of 4-Chloro-1,2-diaminobenzene?

A: Molecular weight of 4-Chloro-1,2-diaminobenzene is 142.586.

Q: How is the water solubility of 4-Chloro-1,2-diaminobenzene?

A: Water solubility of 4-Chloro-1,2-diaminobenzene: 16 g/L (20 ºC).

Q: What is the InChIKey of 4-Chloro-1,2-diaminobenzene?

A: InChIKey of 4-Chloro-1,2-diaminobenzene is BXIXXXYDDJVHDL-UHFFFAOYSA-N.

Q: What are the downstream products of 4-Chloro-1,2-diaminobenzene?

A: Related downstream products(CAS) of 4-Chloro-1,2-diaminobenzene: 39811-14-8;5448-43-1;3584-66-5;14225-75-3;144729-44-2;14537-47-4;4887-82-5;2818-69-1;51-17-2;94-97-3.

Q: What is the English name of 4-Chloro-1,2-diaminobenzene?

A: The English name of 4-Chloro-1,2-diaminobenzene is 4-Chloro-1,2-diaminobenzene.

Q: What is the polar surface area (PSA) of 4-Chloro-1,2-diaminobenzene?

A: Polar surface area (PSA) of 4-Chloro-1,2-diaminobenzene is 52.04000.

Q: What is the CAS number of 4-Chloro-1,2-diaminobenzene?

A: CAS number of 4-Chloro-1,2-diaminobenzene is 95-83-0.

Q: What is the SMILES notation of 4-Chloro-1,2-diaminobenzene?

A: SMILES notation of 4-Chloro-1,2-diaminobenzene is Nc1ccc(Cl)cc1N.

Q: What is the safety information for 4-Chloro-1,2-diaminobenzene?

A: Safety information for 4-Chloro-1,2-diaminobenzene: S26-S36/37.

Q: What are the upstream materials of 4-Chloro-1,2-diaminobenzene?

A: Related upstream materials(CAS) of 4-Chloro-1,2-diaminobenzene: 89-63-4;1635-61-6;17348-69-5;2207-32-1;610-40-2;7440-66-6;881-51-6;106-47-8;52184-29-9;5228-61-5.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Chlorobenzene-1,2-diamine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Chloro-1,2-diaminobenzene
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-Chloro-o-phenylenediamine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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4-Chlorobenzene-1,2-diamine

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles15

4-Chlorobenzene-1,2-diamineBioassay

Synonyms

4-Chlorobenzene-1,2-diamine | FAQ

4-Chlorobenzene-1,2-diaminefactory

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.