4-Chlorobenzene-1,2-diamine

Modify Date: 2024-01-02 18:55:46

4-Chlorobenzene-1,2-diamine structure	Common Name	4-Chlorobenzene-1,2-diamine
	CAS Number	95-83-0	Molecular Weight	142.586
	Density	1.3±0.1 g/cm3	Boiling Point	300.2±22.0 °C at 760 mmHg
	Molecular Formula	C₆H₇ClN₂	Melting Point	70-73 °C(lit.)
	MSDS	Chinese USA	Flash Point	135.4±22.3 °C
	Symbol	GHS07, GHS08	Signal Word	Warning

Name	4-Chloro-1,2-diaminobenzene
Synonym	More Synonyms

Density	1.3±0.1 g/cm3
Boiling Point	300.2±22.0 °C at 760 mmHg
Melting Point	70-73 °C(lit.)
Molecular Formula	C₆H₇ClN₂
Molecular Weight	142.586
Flash Point	135.4±22.3 °C
Exact Mass	142.029770
PSA	52.04000
LogP	1.15
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.671
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	16 g/L (20 ºC)

4-Chlorobenzene-1,2-diamine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SS8850000

CHEMICAL NAME :: o-Phenylenediamine, 4-chloro-

CAS REGISTRY NUMBER :: 95-83-0

BEILSTEIN REFERENCE NO. :: 0508472

LAST UPDATED :: 199710

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: C6-H7-Cl-N2

MOLECULAR WEIGHT :: 142.60

WISWESSER LINE NOTATION :: ZR BZ DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 135 gm/kg/77W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 324 gm/kg/77W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 273 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 917 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 136 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40500 gm/kg/96W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18750 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 14,207,1989 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,81,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,81,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H315-H319-H335-H351
Precautionary Statements	P261-P281-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn:Harmful;
Risk Phrases	R36/37/38;R40
Safety Phrases	S26-S36/37
RIDADR	2811
WGK Germany	3
RTECS	SS8850000
Packaging Group	I; II; III
Hazard Class	6.1
HS Code	2921590090

Precursor 10
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DownStream 10
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HS Code	2921590090
Summary	2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.

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A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above u...

4-Chloro-ortho-phenylenediamine and 4-chloro-meta-phenylenediamine.

IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 27 , 81-9, (1982)

Carcinogenicity of 4-chloro-o-phenylenediamine, 4-chloro-m-phenylenediamine, and 2-chloro-p-phenylenediamine in Fischer 344 rats and B6C3F1 mice.

Carcinogenesis 1(6) , 495-9, (1980)

In both male and female Fischer rats, feeding 4-chloro-o-phenylenediamine at 0.5 or 1% in the diet led to a significant increase in hyperplasia, papilloma and carcinoma of the urinary bladder. Neoplas...

EINECS 202-456-8

4-Chloro-1,2-phenylenediamine

4-Chlorobenzene-1,2-diamine

4-Chloro-1,2-diaminobenzene

4-Chloro-1,2-benzenediamine

MFCD00011691

ZR BZ DG

1,2-Benzenediamine, 4-chloro-

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-Chlorobenzene-1,2-diamine
Price: ￥278.0/25g ￥98.0/5g
Purity: 97.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Chloro-1,2-diaminobenzene
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 4-Chloro-o-phenylenediamine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-Chloro-o-phenylenediamine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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4-Chlorobenzene-1,2-diamine

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