Propargyl-PEG-amine

Modify Date: 2024-01-16 11:47:14

Propargyl-PEG-amine Structure
Propargyl-PEG-amine structure
Common Name Propargyl-PEG-amine
CAS Number 956348-61-1 Molecular Weight 1112.340
Density 1.1±0.1 g/cm3 Boiling Point 911.7±60.0 °C at 760 mmHg
Molecular Formula (C2H4O)nC5H9NO Melting Point N/A
MSDS N/A Flash Point 479.1±26.6 °C

 Use of Propargyl-PEG-amine


Propargyl-PEG-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72-Tetracosaoxapentaheptacont-74-yn-1-amine
Synonym More Synonyms

 Propargyl-PEG-amine Biological Activity

Description Propargyl-PEG-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 911.7±60.0 °C at 760 mmHg
Molecular Formula (C2H4O)nC5H9NO
Molecular Weight 1112.340
Flash Point 479.1±26.6 °C
Exact Mass 1111.671387
LogP -8.34
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.469

 Synonyms

MFCD30723251
3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72-Tetracosaoxapentaheptacont-74-yn-1-amine