GRK2-IN-1 structure
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Common Name | GRK2-IN-1 | ||
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CAS Number | 2055990-90-2 | Molecular Weight | 452.48 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C24H25FN4O4 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of GRK2-IN-1GRKs-IN-1, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=30 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1]. |
Name | GRK2-IN-1 |
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Description | GRKs-IN-1, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=30 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1]. |
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Related Catalog | |
Target |
GRK2:30 nM (IC50) GRK5:7.1 μM (IC50) |
References |
Molecular Formula | C24H25FN4O4 |
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Molecular Weight | 452.48 |