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L-655238

L-655238用途

REV 5901是一种竞争性口服活性白三烯受体拮抗剂,Ki为0.7μM。REV 5901也是一种5-脂氧合酶抑制剂。REV 5901可用于白三烯释放可能涉及的哮喘研究[1][2]。

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L-655238名称

[ CAS 号 ]:
101910-24-1

[ 英文名 ]:
L-655238

[英文别名 ]:

rev-5901
rg 5901
Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-
1-[3-(2-Quinolinylmethoxy)phenyl]-1-hexanol
pf 5901
1-[3-(Quinolin-2-ylmethoxy)phenyl]hexan-1-ol

L-655238生物活性

[ 描述 ]:

REV 5901是一种竞争性口服活性白三烯受体拮抗剂,Ki为0.7μM。REV 5901也是一种5-脂氧合酶抑制剂。REV 5901可用于白三烯释放可能涉及的哮喘研究[1][2]。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 白三烯受体

研究领域 >> 炎症/免疫

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

[ 靶点 ]

Ki: 0.7 μM (leukotriene receptor)[1] [2]

[参考文献]

[1]. Inwegen RGV, et, al. REV 5901: an orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile. J Pharmacol Exp Ther. 1987 Apr;241(1):117-24.

[2]. Anderson G, et, al. Effects of REV 5901, a 5-lipoxygenase inhibitor and leukotriene antagonist, on pulmonary responses to platelet activating factor in the guinea-pig. Br J Pharmacol. 1988 Aug;94(4):1115-22.

L-655238物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
497.7±35.0 °C at 760 mmHg

[ 分子式 ]:
C₂₂H₂₅NO₂

[ 分子量 ]:
335.439

[ 闪点 ]:
254.8±25.9 °C

[ 精确质量 ]:
335.188538

[ PSA ]:
42.35000

[ LogP ]:
4.94

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.606

L-655238MSDS

L-655238安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

L-655238合成路线

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L-655238文献

Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes.

Inflammation 26(2) , 61-71, (2002)

The initial phase of zymosan-induced peritonitis involves an increase of vascular permeability (peak at 30 min) that is correlated with high levels of vasoactive eicosanoids, namely, prostaglandins (P...

Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine.

Eur. J. Pharmacol. 459(1) , 27-39, (2003)

Conventional intracellular microelectrodes, neuronal tracer injection techniques and immunohistochemistry were used to study the actions of cysteinyl leukotrienes (CysLTs) on electrical and synaptic b...

Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines.

J. Cell Physiol. 192(2) , 188-99, (2002)

The effects of LY-171883, an orally active leukotriene antagonist, on membrane currents were examined in pituitary GH(3) and in neuroblastoma IMR-32 cells. In GH(3) cells, LY-171883 (1-300 microM) rev...

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