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西替酰胺

西替酰胺用途

Citenamide 是一种抗惊厥药,具有镇静、催眠效果。

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西替酰胺名称

[ CAS 号 ]:
10423-37-7

[ 中文名 ]:
西替酰胺

[ 英文名 ]:
Citenamide

[英文别名 ]:

Citenamide
Dibenzo<a,e>cycloheptatrien-5-carboxamid
5H-Dibenzo<a.d>cyclohepten-5-carbonsaeureamid
Dibenzo<a,e>1,3,5-cycloheptatrien-5-carboxamid
Cytenamide
AY-15,613
percentH-Dibenzo<a,b>cyclohepten-5-carboxamid

西替酰胺生物活性

[ 描述 ]:

Citenamide 是一种抗惊厥药,具有镇静、催眠效果。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体内研究]

Citenamide(Cytenamide,CYT)是Carbamazepine(CBZ)的类似物,Carzamazepine是一种用于控制癫痫发作的二苯并氮杂类药物。

[参考文献]

[1]. Johnston A, et al. Cytenamide-formic acid (1/1). Acta Crystallogr Sect E Struct Rep Online. 2008 Jul 5;64(Pt 8):o1379-80.

[相关活性小分子]

西替酰胺物理化学性质

[ 密度 ]:
1.203g/cm3

[ 沸点 ]:
487.1ºC at 760 mmHg

[ 分子式 ]:
C₁₆H₁₃NO

[ 分子量 ]:
235.28100

[ 闪点 ]:
248.4ºC

[ 精确质量 ]:
235.10000

[ PSA ]:
43.09000

[ LogP ]:
3.48790

[ 蒸汽压 ]:
1.23E-09mmHg at 25°C

[ 折射率 ]:
1.643

[ 储存条件 ]:
2-8℃

西替酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HO7700000

CHEMICAL NAME :: 5H-Dibenzo(a,d)cycloheptene-5-carboxamide

CAS REGISTRY NUMBER :: 10423-37-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H13-N-O

MOLECULAR WEIGHT :: 235.30

WISWESSER LINE NOTATION :: L C676 BHJ BVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,65,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,65,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,65,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 582 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,88,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,91,1972

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西替酰胺安全信息

[ 海关编码 ]:
2924299090

西替酰胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%