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二苯甲酰甲烷

二苯甲酰甲烷用途

Dibenzoylmethane 是甘草中的次要成分,可激活 Nrf2 并预防各种癌症和氧化损伤。Dibenzoylmethane 是姜黄素的类似物,会引起 Keap1 解离和 Nrf2 的核易位。

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二苯甲酰甲烷名称

[ CAS 号 ]:
120-46-7

[ 中文名 ]:
二苯甲酰基甲烷

[ 英文名 ]:
1,3-Diphenylpropane-1,3-dione

[中文别名 ]:

[英文别名 ]:

1,3-Diphenyl-1,3-propanedione
1,3-diphenylpropane-1,3-dione
Dibenzoylmethane
MFCD00003085
phenacyl phenyl ketone
EINECS 204-398-9
1,3-Propanedione, 1,3-diphenyl-

二苯甲酰甲烷生物活性

[ 描述 ]:

Dibenzoylmethane 是甘草中的次要成分,可激活 Nrf2 并预防各种癌症和氧化损伤。Dibenzoylmethane 是姜黄素的类似物,会引起 Keap1 解离和 Nrf2 的核易位。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> NF-κB信号通路 >> KEAP1-Nrf2

研究领域 >> 代谢疾病

[体外研究]

二苯甲酰甲烷(10,20,30,40,50μ米；6小时)浓度依赖性地增加HepG2细胞HO-1的mRNA水平,但不影响Nrf2的mRNA水平。二苯甲酰甲烷诱导HO-1和Nrf2蛋白表达,12小时后诱导减弱[1]。二苯甲酰甲烷(10,20,30,40,50μ米；2小时)浓度依赖性地增加HepG2细胞中Erk1/2、p38MAPK、JNK、AMPK和Akt的磷酸化蛋白水平。二苯甲酰甲烷没有显示出明显的细胞毒性[1]。

[体内研究]

二苯甲酰甲烷(200mg/kg/天；知识产权；连续三天)在剂量为200mg/kg的野生型和Nrf2基因敲除小鼠中,预处理显著减少坏死的面积和严重程度以及白细胞浸润[1]。二苯甲酰甲烷对四氯化碳(1:49,v/v,10ml/kg)诱导的野生型小鼠肝损伤有保护作用[1]。

[参考文献]

[1]. Mingnan Cao, et al. Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling. AAPS J. 2017 Nov;19(6):1703-1714.

二苯甲酰甲烷物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
357.4±0.0 °C at 760 mmHg

[ 熔点 ]:
77-79 °C(lit.)

[ 分子式 ]:
C₁₅H₁₂O₂

[ 分子量 ]:
224.255

[ 闪点 ]:
146.9±20.2 °C

[ 精确质量 ]:
224.083725

[ PSA ]:
34.14000

[ LogP ]:
3.04

[ 外观性状 ]:
淡黄色-白色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.584

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

二苯甲酰甲烷MSDS

详细MSDS(安全技术说明书)

二苯甲酰甲烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ1930000

CHEMICAL NAME :: 1,3-Propanedione, 1,3-diphenyl-

CAS REGISTRY NUMBER :: 120-46-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H12-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,28,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4833 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

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二苯甲酰甲烷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TZ1930000

[ 海关编码 ]:
2914399090

二苯甲酰甲烷合成路线

详细合成路线

二苯甲酰甲烷上下游产品

二苯甲酰甲烷上游产品

二苯甲酰甲烷下游产品

二苯甲酰甲烷制备

由苄叉乙酰基苯为原料，经溴化、水解得到。

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二苯甲酰甲烷海关

[ 海关编码 ]: 2914399090

[ 中文概述 ]:
2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

二苯甲酰甲烷文献

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

J. Med. Chem. 48 , 2906-15, (2005)

Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of different classes, the identification of ...

A glimpse of the inner workings of the templated site.

Chem. Commun. (Camb.) (2) , 165-7, (2009)

This is the first direct experimental probe, using EXAFS, of the active site within molecularly imprinted polymers and paves the way to a more detailed understanding of the inner workings of molecular...

Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors.

J. Med. Chem. 51 , 6478-94, (2008)

Hormone sensitive lipase (HSL) has been recently implicated in diabetes and obesity, prompting attempts to discover new HSL inhibitors. Toward this end, we explored the pharmacophoric space of HSL inh...

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二苯甲酰甲烷

二苯甲酰甲烷用途

二苯甲酰甲烷名称

二苯甲酰甲烷生物活性

二苯甲酰甲烷物理化学性质

二苯甲酰甲烷MSDS

详细MSDS(安全技术说明书)

二苯甲酰甲烷毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

二苯甲酰甲烷安全信息

二苯甲酰甲烷合成路线

详细合成路线

二苯甲酰甲烷上下游产品

二苯甲酰甲烷上游产品

二苯甲酰甲烷下游产品

二苯甲酰甲烷制备

二苯甲酰甲烷海关

二苯甲酰甲烷文献

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