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壬二酸

壬二酸用途

Azelaic acid是一种由油酸臭氧分解产生的有机化合物,头发和皮肤调理剂的组分。

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壬二酸名称

[ CAS 号 ]:
123-99-9

[ 中文名 ]:
杜鹃花酸

[ 英文名 ]:
Azelaic acid

[中文别名 ]:

[英文别名 ]:

Skinoren
AZALEIC ACID
Azelaate
3,4-Dimethoxybenzaldehyde
Nonanedioic acid
Azelaic acid
UNII-F2VW3D43YT
AZELAIC ACID/NONANEDIOIC ACID
Barasertib
AZELAIC ACID FOR SYNTHESIS

壬二酸生物活性

[ 描述 ]:

Azelaic acid是一种由油酸臭氧分解产生的有机化合物,头发和皮肤调理剂的组分。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Jung HW, et al. Priming in systemic plant immunity. Science. 2009 Apr 3;324(5923):89-91.

[2]. Liu RH, et al. Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. Arch Dermatol. 2006 Aug;142(8):1047-52.

[相关活性小分子]

壬二酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
286 ºC (100 mmHg)

[ 熔点 ]:
98-103 ºC

[ 分子式 ]:
C₉H₁₆O₄

[ 分子量 ]:
188.221

[ 闪点 ]:
215 ºC

[ 精确质量 ]:
188.104858

[ PSA ]:
74.60000

[ LogP ]:
1.33

[ 外观性状 ]:
白色片状

[ 蒸汽密度 ]:
6.5 (vs air)

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.475

[ 储存条件 ]:
通风低温干燥,与氧化剂分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with bases, strong oxidizing agents. Readily biodegrades in soil and water with >70% DOC reduction after 28 days.

[ 水溶解性 ]:
2.4 g/L (20 ºC)

壬二酸MSDS

壬二酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CM1980000

CHEMICAL NAME :: Azelaic acid

CAS REGISTRY NUMBER :: 123-99-9

BEILSTEIN REFERENCE NO. :: 1101094

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C9-H16-O4

MOLECULAR WEIGHT :: 188.25

WISWESSER LINE NOTATION :: QV7VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati, OH 45232) Volume(issue)/page/year: S3B,-,1964

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EMERY* Emery Industries, Inc., Data Sheets. (4900 Este Ave., Cincinnati, OH 45232) Volume(issue)/page/year: S3B,-,1964 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A067-313 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83495 No. of Facilities: 170 (estimated) No. of Industries: 8 No. of Occupations: 11 No. of Employees: 1676 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83495 No. of Facilities: 3427 (estimated) No. of Industries: 35 No. of Occupations: 42 No. of Employees: 34469 (estimated) No. of Female Employees: 7576 (estimated)

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壬二酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
CM1980000

[ 海关编码 ]:
2917139000

壬二酸合成路线

壬二酸上下游产品

壬二酸上游产品

壬二酸下游产品

壬二酸制备

【方法一】
由油酸经硝酸氧化或臭氧氧化而得。也可以用工业蓖麻作原料裂解而得。1,5-二溴戊烷与乙腈缩合，或者以戊二酸单甲酯单酰氰为原料经酮式壬二酸二甲酯都可以制取壬二酸。

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壬二酸海关

[ 海关编码 ]: 2917139000

[ 中文概述 ]:
2917139000 其他壬二酸及其盐和酯。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917139000 azelaic acid, sebacic acid, their salts and esters VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

壬二酸文献

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

更多文献

壬二酸

壬二酸用途

壬二酸名称

壬二酸生物活性

壬二酸物理化学性质

壬二酸MSDS

详细MSDS(安全技术说明书)

壬二酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

壬二酸安全信息

壬二酸合成路线

详细合成路线

壬二酸上下游产品

壬二酸上游产品

壬二酸下游产品

壬二酸制备

壬二酸海关

壬二酸文献

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