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ZM 241385

ZM 241385用途

ZM 241385是选择性和高亲和力的A2A腺苷受体拮抗剂。

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ZM 241385名称

[ CAS 号 ]:
139180-30-6

[ 中文名 ]:
ZM 241385

[ 英文名 ]:
ZM 241385

[英文别名 ]:

ZM241385

ZM 241385生物活性

[ 描述 ]:

ZM 241385是选择性和高亲和力的A2A腺苷受体拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

研究领域 >> 神经疾病

[参考文献]

[1]. Poucher SM, et al. The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist. Br J Pharmacol. 1995 Jul;115(6):1096-102.

[相关活性小分子]

ZM 241385物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 分子式 ]:
C₁₆H₁₅N₇O₂

[ 分子量 ]:
337.336

[ 精确质量 ]:
337.128723

[ PSA ]:
127.39000

[ LogP ]:
0.89

[ 外观性状 ]:
粉末

[ 折射率 ]:
1.791

[ 储存条件 ]:
-20℃

ZM 241385MSDS

详细MSDS(安全技术说明书)

ZM 241385安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

ZM 241385文献

Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish.

Zebrafish 12(2) , 127-36, (2015)

Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties. Thus, the modulation exerted by adenosine might be an effective tool to control seizures. In thi...

Constitutive phospholipid scramblase activity of a G protein-coupled receptor.

Nat. Commun. 5 , 5115, (2014)

Opsin, the rhodopsin apoprotein, was recently shown to be an ATP-independent flippase (or scramblase) that equilibrates phospholipids across photoreceptor disc membranes in mammalian retina, a process...

Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.

J. Inflamm. (Lond.) 11(1) , 37, (2014)

Adenosine is produced at high levels at inflamed sites as a by-product of cellular activation and breakdown. Adenosine mediates its anti-inflammatory activity primarily through the adenosine A2a recep...

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