< 生产厂家 价格 >

多索茶碱

多索茶碱用途

Doxofylline 是腺苷 A1 受体 (adenosine A1 receptor) 的拮抗剂,且能抑制磷酸二酯酶 IV (phosphodiesterase IV)。
点击显示

多索茶碱名称

[ CAS 号 ]:
69975-86-6

[ 中文名 ]:
多索茶碱

[ 英文名 ]:
Doxofylline

[中文别名 ]:

[英文别名 ]:

多索茶碱生物活性

[ 描述 ]:

Doxofylline 是腺苷 A1 受体 (adenosine A1 receptor) 的拮抗剂,且能抑制磷酸二酯酶 IV (phosphodiesterase IV)。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体
信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
研究领域 >> 炎症/免疫

[ 靶点 ]

Adenosine A1 receptor, phosphodiesterase IV[1]


[参考文献]

[1]. Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10(14):2343-56.


[相关活性小分子]

3-异丁基-1-甲基黄嘌呤 | 咯利普兰 | PF-04957325 | 克立硼罗 | CGS 21680盐酸盐 | GLPG1690 | 瑞德南特 | Bay 60-7550 | 淫羊藿苷 | ZM 241385 | 异丁司特 | 4-[3-氧代-3-(2-氧代-2,3-二氢苯并恶唑-6-基)丙基]哌嗪-1-羧酸 3,5-二氯苄酯 | TAK-063 | CPI-444 | 2-(2-呋喃基)-7-(2-苯基乙基)-7H-吡唑并[4,3-e][1,2,4]噻唑并[1,5-c]嘧啶-5-胺

多索茶碱物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
505.2±53.0 °C at 760 mmHg

[ 熔点 ]:
144-146ºC

[ 分子式 ]:
C11H14N4O4

[ 分子量 ]:
266.253

[ 闪点 ]:
259.3±30.9 °C

[ 精确质量 ]:
266.101501

[ PSA ]:
80.28000

[ LogP ]:
-0.70

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.700

[ 储存条件 ]:
室温

[ 水溶解性 ]:
Soluble

多索茶碱MSDS

详细MSDS(安全技术说明书)

多索茶碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH5135000
CHEMICAL NAME :
Theophylline, 7-(1,3-dioxolan-2-ylmethyl)-
CAS REGISTRY NUMBER :
69975-86-6
BEILSTEIN REFERENCE NO. :
0561195
LAST UPDATED :
199806
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C11-H14-N4-O4
MOLECULAR WEIGHT :
266.29
WISWESSER LINE NOTATION :
T56 BN DN FNVNVJ F1 H1 B1- BT5O COTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
965 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4868186
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
426 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
315 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
841 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,201,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
396 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
216 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,201,1981
点击显示

多索茶碱安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

多索茶碱制备

【方法一】
茶碱溶于沸水，加入氢氧化钠和3-氯-1，2-丙二醇，回流。蒸去水后用乙醇重结晶，得化合物(I)，收率95%。
化合物(I)溶于水，搅拌下加入等摩尔的HIO4?2H2O，搅拌。滤集固体，乙醇重结晶，得茶碱乙醛，收率70%。
茶碱乙醛、乙二醇和对甲苯磺酸在苯中回流脱水，得多索茶碱，收率70%。
点击显示

多索茶碱文献

Doxofylline, an antiasthmatic drug lacking affinity for adenosine receptors.

Arch. Int. Pharmacodyn. Ther. 295 , 221-37, (1988)

In the present study the interaction of doxofylline, a new antiasthmatic drug, with A1- and A2-adenosine receptors of the guinea-pig brain and rat striatum was investigated in comparison with known me...

Doxofylline in rat brain in relation to locomotor activity.

Drug Metab. Dispos. 17(4) , 437-40, (1989)

Doxofylline is a new xanthine derivative with significant bronchodilatatory activity. We have studied in HPLC the distribution of doxofylline in various areas of rat brain (cortex, cerebellum, limbic ...

The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients.

Aliment. Pharmacol. Ther. 4(6) , 643-9, (1990)

The aim of this study was to compare the effects upon gastric secretion of therapeutic doses of aminophylline, with doxofylline, a new xanthine derivative proposed for the treatment of chronic asthma....


更多文献

相关药品：

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：多索茶碱

公司名：云南西力生物技术股份有限公司

区域：昆明市盘龙区

价格：
￥需询单/5mg

联系人：郑雪平

产品详情：多索茶碱

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥198.0/250mg ￥348.0/25g ￥108.0/5g

联系人：刘佳

产品详情：多索茶碱

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Doxofylline

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥389.0/50mg ￥489.0/1g ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：Doxofylline

查看所有供应商请点击：

多索茶碱供应商

相关化合物

【多索茶碱】化源网提供多索茶碱CAS号69975-86-6，多索茶碱MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询多索茶碱上化源网，专业又轻松。>>电脑版：多索茶碱

标题：多索茶碱_MSDS_用途_密度_多索茶碱CAS号【69975-86-6】_化源网 地址：https://m.chemsrc.com/mip/cas/69975-86-6_330761.html