磺胺甲二唑

磺胺甲二唑用途

Sulfamethizole是磺胺噻唑类抗生素,能抑制细菌的PABA。

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磺胺甲二唑作用

磺胺甲噻二唑是细菌对氨基苯甲酸（PABA）的竞争性抑制剂，PABA是二氢蝶酸合成酶的底物。在这些生物体中，抑制反应是合成叶酸所必需的。磺胺甲噻二唑是二氢蝶酸合成酶的抑制剂和叶酸的形成，抑制生物发光而不是生长。用磺胺甲噻二唑处理导致来自敏感菌株（MIC，128微克/毫升）和抗性菌株（MIC，512微克/毫升）的所有样品中细菌计数的显着减少。用sulⅡ基因阳性菌株（MIC，> 2,048微克/毫升）感染不能用磺胺甲噻二唑治疗，因为在尿液，膀胱或肾脏中没有效果。

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磺胺甲二唑名称

[ CAS 号 ]:
144-82-1

[ 中文名 ]:
磺胺甲噻二唑

[ 英文名 ]:
Sulfamethizole

[中文别名 ]:

[英文别名 ]:

MFCD00053363
Sulfamethizole
Sulfarine
EINECS 205-641-1
Sulphamethizole

磺胺甲二唑生物活性

[ 描述 ]:

Sulfamethizole是磺胺噻唑类抗生素,能抑制细菌的PABA。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> PD-1/PD-L1

研究领域 >> 感染

[参考文献]

[1]. Watanabe, H. and J.W. Hastings, Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta, 1990. 1017(3): p. 229-34.

[2]. Kerrn, M.B., N. Frimodt-Moller, and F. Espersen, Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. Antimicrob Agents Chemother, 2003. 47(3): p. 1002-9.

[相关活性小分子]

磺胺甲二唑物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
504.9±52.0 °C at 760 mmHg

[ 熔点 ]:
210 °C

[ 分子式 ]:
C₉H₁₀N₄O₂S₂

[ 分子量 ]:
270.331

[ 闪点 ]:
259.1±30.7 °C

[ 精确质量 ]:
270.024506

[ PSA ]:
134.59000

[ LogP ]:
0.51

[ 外观性状 ]:
白色至淡黄色结晶粉末

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.687

[ 储存条件 ]:
2-8°C

磺胺甲二唑MSDS

详细MSDS(安全技术说明书)

磺胺甲二唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WP0875000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(5-methyl-1,3,4-thiadiazol-2-yl)-

CAS REGISTRY NUMBER :: 144-82-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C9-H10-N4-O2-S2

MOLECULAR WEIGHT :: 270.35

WISWESSER LINE NOTATION :: T5NN DSJ CMSWR DZ& E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4444 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1820 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3668 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6000 mg/kg/4W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumor types after systemic administration not seen spontaneously

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Mold - Aspergillus nidulans

DOSE/DURATION :: 1 gm/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974 *** REVIEWS *** TOXICOLOGY REVIEW DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 2(1),2,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83544 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83544 No. of Facilities: 19 (estimated) No. of Industries: 2 No. of Occupations: 15 No. of Employees: 1635 (estimated) No. of Female Employees: 255 (estimated)

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磺胺甲二唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R43

[ 安全声明 (欧洲) ]:
S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
WP0875000

[ 海关编码 ]:
2935009090

磺胺甲二唑合成路线

详细合成路线

磺胺甲二唑上下游产品

磺胺甲二唑上游产品

磺胺甲二唑下游产品

磺胺甲二唑海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

磺胺甲二唑文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

更多文献

磺胺甲二唑

磺胺甲二唑用途

磺胺甲二唑作用

磺胺甲二唑名称

磺胺甲二唑生物活性

磺胺甲二唑物理化学性质

磺胺甲二唑MSDS

详细MSDS(安全技术说明书)

磺胺甲二唑毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

磺胺甲二唑安全信息

磺胺甲二唑合成路线

详细合成路线

磺胺甲二唑上下游产品

磺胺甲二唑上游产品

磺胺甲二唑下游产品

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磺胺甲二唑文献

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