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瑞舒伐他汀钙

瑞舒伐他汀钙用途

Rosuvastatin钙盐是HMG-CoA还原酶抑制剂,IC50为11 nM。

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瑞舒伐他汀钙名称

[ CAS 号 ]:
147098-20-2

[ 中文名 ]:
罗苏伐他汀钙

[ 英文名 ]:
Rosuvastatin Calcium

[中文别名 ]:

[英文别名 ]:

MFCD04112702
Crestor
Rosuvastatin Calcium
Rosuvastatin (Calcium)

瑞舒伐他汀钙生物活性

[ 描述 ]:

Rosuvastatin钙盐是HMG-CoA还原酶抑制剂,IC50为11 nM。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)

研究领域 >> 代谢疾病

[参考文献]

[1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44.

[2]. Kim, Y.S., et al., Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and Nuclear Factor-kappaB in endothelial cells. J Cardiovasc Pharmacol, 2007. 49(6): p. 376-83.

[3]. Carswell, C.I., G.L. Plosker, and B. Jarvis, Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7.

[4]. Stalker, T.J., A.M. Lefer, and R. Scalia, A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br J Pharmacol, 2001. 133(3): p. 406-12.

[5]. Schneck, D.W., et al., The effect of gemfibrozil on the pharmacokinetics of rosuvastatin. Clin Pharmacol Ther, 2004. 75(5): p. 455-63.

[相关活性小分子]

瑞舒伐他汀钙物理化学性质

[ 沸点 ]:
745.6ºC at 760 mmHg

[ 熔点 ]:
122ºC

[ 分子式 ]:
C₂₂H₂₇Ca_0.5FN₃O₆S

[ 分子量 ]:
500.57

[ 闪点 ]:
404.7ºC

[ PSA ]:
304.26000

[ LogP ]:
4.29560

[ 外观性状 ]:
白色至灰白色结晶固体

[ 储存条件 ]:
-20°C Freezer

瑞舒伐他汀钙安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2935009090

瑞舒伐他汀钙海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%