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美伐他汀

美伐他汀用途

Mevastatin (Compactin; ML236B)抑制HMG-CoA还原酶(HMGCR),可抑制类异戊二烯的生物合成,阻断蛋白的异戊二烯化,降低血浆胆固醇水平。

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美伐他汀名称

[ CAS 号 ]:
73573-88-3

[ 中文名 ]:
美伐他汀

[ 英文名 ]:
Mevastatin

[中文别名 ]:

[英文别名 ]:

ML 236B
Mevastatinum [INN-Latin]
mevastatin
Compactin (penicillium)
Antibiotic ML 236B
Mevastatin (Compactin)
MFCD05662341
Statin I
(+)-Compactin
ML 236 B

美伐他汀生物活性

[ 描述 ]:

Mevastatin (Compactin; ML236B)抑制HMG-CoA还原酶(HMGCR),可抑制类异戊二烯的生物合成,阻断蛋白的异戊二烯化,降低血浆胆固醇水平。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)

研究领域 >> 癌症

[参考文献]

[1]. Sugazaki M, Hirotani H, Echigo S, et al. Effects of mevastatin on grafted bone in MRL/MpJ mice. Connect Tissue Res. 2010 Apr;51(2):105-12. doi: 10.3109/03008200903105098.

[2]. Evangelopoulos ME, Weis J, Krüttgen A. Mevastatin-induced neurite outgrowth of neuroblastoma cells via activation of EGFR. J Neurosci Res. 2009 Jul;87(9):2138-44. doi: 10.1002/jnr.22025.

[3]. W?chtersh?user A, Akoglu B, Stein J. HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. Carcinogenesis. 2001 Jul;22(7):1061-7.

[4]. Amin-Hanjani S, Stagliano NE, Yamada M, et al. Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke. 2001 Apr;32(4):980-6.

[相关活性小分子]

美伐他汀物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
555.0±50.0 °C at 760 mmHg

[ 熔点 ]:
151-153 °C

[ 分子式 ]:
C₂₃H₃₄O₅

[ 分子量 ]:
390.513

[ 闪点 ]:
186.5±23.6 °C

[ 精确质量 ]:
390.240631

[ PSA ]:
72.83000

[ LogP ]:
3.57

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±3.4 mmHg at 25°C

[ 折射率 ]:
1.535

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: 20 mg/mL

美伐他汀MSDS

美伐他汀毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7907100

CHEMICAL NAME :: Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hy droxy-6-oxo-2H-pyran- 2-yl)ethyl)-1-naphthalenyl ester, (1S-(1-alpha(R*),7-beta,8-beta(2S*,4S*),8a-beta))-

CAS REGISTRY NUMBER :: 73573-88-3

LAST UPDATED :: 199212

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C23-H34-O5

MOLECULAR WEIGHT :: 390.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 29,1346,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 29,1346,1976

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美伐他汀安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
EK7907100

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美伐他汀文献

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Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Chemical profiling and quantification of monacolins and citrinin in red yeast rice commercial raw materials and dietary supplements using liquid chromatography-accurate QToF mass spectrometry: Chemometrics application.

J. Pharm. Biomed. Anal. 100 , 243-53, (2014)

Red yeast rice (RYR) is prepared by fermenting rice with various strains of the yeast Monascus spp of the Aspergillaceae family. Depending on the Monascus strains and the fermentation conditions, the ...

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