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氟伐他汀钠

氟伐他汀钠用途

Fluvastatin钠是HMG-CoA还原酶竞争性抑制剂。

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氟伐他汀钠名称

[ CAS 号 ]:
93957-55-2

[ 中文名 ]:
氟伐他汀钠

[ 英文名 ]:
Fluvastatin Sodium

[中文别名 ]:

[英文别名 ]:

Fluvastatin sodium salt
Lipaxan
MFCD00929076
XU 62-320
fluindostatin
Fluvastatin sodium
Fluvastatinsodium
Fluvastatin (sodium)

氟伐他汀钠生物活性

[ 描述 ]:

Fluvastatin钠是HMG-CoA还原酶竞争性抑制剂。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)

研究领域 >> 心血管疾病

[参考文献]

[1]. Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24. [Epub ahead of print]

[2]. Makabe S, Takahashi Y, Watanabe H, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84.

[3]. Zhang W, Wu J, Zhou L, et al. Fluvastatin, a lipophilic statin, induces apoptosis in human hepatocellular carcinoma cells through mitochondria-operated pathway. Indian J Exp Biol. 2010 Dec;48(12):1167-74.

[4]. Scripture CD, Pieper JA. Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81.

[相关活性小分子]

氟伐他汀钠物理化学性质

[ 沸点 ]:
681.8ºC at 760 mmHg

[ 熔点 ]:
194-197ºC

[ 分子式 ]:
C₂₄H₂₆FNNaO₄+

[ 分子量 ]:
434.46

[ PSA ]:
85.52000

[ LogP ]:
3.29340

[ 外观性状 ]:
固体;Light orange to Yellow to Green powder to crystal

[ 储存条件 ]:
Desiccate at -20°C

[ 水溶解性 ]:
可溶于：甲醇

氟伐他汀钠MSDS

详细MSDS(安全技术说明书)

氟伐他汀钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MJ9675100

CHEMICAL NAME :: 6-Heptenoic acid, 3,5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1 H-indol-2-yl)-, monosodium salt, (R*,S*-(E))-, (+-)-

CAS REGISTRY NUMBER :: 93957-55-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C24-H26-F-N-O4.Na

MOLECULAR WEIGHT :: 434.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2912 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 29,48,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 5824 mg/kg/2Y-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 29,48,1996 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 396 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 29,853,1995

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氟伐他汀钠安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

氟伐他汀钠海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

氟伐他汀钠文献

Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys.

Drug Metab. Pharmacokinet. 30(2) , 198-204, (2015)

Since drug-drug interaction (DDI) can affect organic anion-transporting polypeptide (OATP) and cause clinical events, prediction of such DDI is important in early clinical development. Although statin...

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice.

APMIS 121(5) , 422-30, (2013)

Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, have been shown to ameliorate a number of vascular diseases. We evaluated the inflammatory and angiogenic components of t...

The effects of different types of statins on proliferation and migration of HGF-induced Human Umbilical Vein Endothelial Cells (HUVECs).

Eur. Rev. Med. Pharmacol. Sci. 17(21) , 2874-83, (2013)

Statins are HMG-CoA reductase inhibitors within the framework of cholesterol biosynthesis and used to lower the low-density lipoprotein (LDL). There are other aspects of statins can deploy a protectiv...

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