胆固醇琥珀酸单酯

胆固醇琥珀酸单酯用途

半琥珀酸酯胆甾醇是一种具有保肝抗癌活性的物质。半琥珀酸酯胆甾醇抑制对乙酰氨基酚(AAP,HY-66005)的肝毒性,并防止AAP诱导的肝细胞凋亡和坏死。半琥珀酸酯胆固醇抑制DNA聚合酶和DNA拓扑异构酶,抑制DNA复制和修复以及细胞分裂。因此,半琥珀酸酯胆固醇抑制肿瘤生长[1][2]。

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胆固醇琥珀酸单酯名称

[ CAS 号 ]:
1510-21-0

[ 中文名 ]:
胆固醇琥珀酸单酯

[ 英文名 ]:
4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid

[中文别名 ]:

[英文别名 ]:

4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid
3-cholesteryloxycarbonylpropanoic acid
Cholesteryl hydrogen succinate
EINECS 216-148-6
3-(3-cholesteryloxycarbonyl)propanoic acid
MONO-CHOLESTERYL-SUCCINATE
CHOLESTEROL HYDROGEN SUCCINATE
3β-Hydroxy-5-cholestene 3-hemisuccinate
MFCD00037705
cholesteryl hemisuccinate free acid

胆固醇琥珀酸单酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

[体内研究]

半琥珀酸酯胆甾醇(100 mg/kg；ip；AAP前单次给药)消除 AAP(350-500 mg/kg；ip单次给药)在集成电路小鼠 (CD-1)中诱导的细胞凋亡和坏死的组织学和生化诊断[1]

[参考文献]

[1]. Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 Dec;279(3):1470-83.

[2]. Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015;2015:746093.

胆固醇琥珀酸单酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
586.0±43.0 °C at 760 mmHg

[ 熔点 ]:
178 °C

[ 分子式 ]:
C₃₁H₅₀O₄

[ 分子量 ]:
486.73

[ 闪点 ]:
179.6±21.7 °C

[ 精确质量 ]:
486.370911

[ PSA ]:
63.60000

[ LogP ]:
10.32

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±3.5 mmHg at 25°C

[ 折射率 ]:
1.529

[ 储存条件 ]:
室温，密封，干燥

胆固醇琥珀酸单酯MSDS

详细MSDS(安全技术说明书)

胆固醇琥珀酸单酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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胆固醇琥珀酸单酯文献

Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.

Biochem. Biophys. Res. Commun. 456(1) , 116-21, (2014)

G protein-coupled receptors (GPCRs) represent the largest family of transmembrane signaling proteins, and they are considered major targets of approximately half of all therapeutic agents. Human melan...

Solution structure of the transmembrane 2 domain of the human melanocortin-4 receptor in sodium dodecyl sulfate (SDS) micelles and the functional implication of the D90N mutant.

Biochim. Biophys. Acta 1848 , 1294-302, (2015)

The melanocortin receptors (MCRs) are members of the G protein-coupled receptor (GPCR) 1 superfamily with seven transmembrane (TM) domains. Among them, the melanocortin-4 receptor (MC4R) subtype has b...

Structural basis for the facilitative diffusion mechanism by SemiSWEET transporter.

Nat. Commun. 6 , 6112, (2015)

SWEET family proteins mediate sugar transport across biological membranes and play crucial roles in plants and animals. The SWEETs and their bacterial homologues, the SemiSWEETs, are related to the PQ...

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