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安普那韦

安普那韦用途

Amprenavir (Agenerase)是HIV蛋白酶抑制剂,Ki为0.6 nM。

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安普那韦名称

[ CAS 号 ]:
161814-49-9

[ 中文名 ]:
安普那韦

[ 英文名 ]:
Amprenavir

[中文别名 ]:

氨普那韦

[英文别名 ]:

Vertex
VX-478
Amprenavir (agenerase)
Prozei
141W94
Vertex VX478
Amprenavir
Agenerase

安普那韦生物活性

[ 描述 ]:

Amprenavir (Agenerase)是HIV蛋白酶抑制剂,Ki为0.6 nM。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> HIV蛋白酶

信号通路 >> 抗感染 >> HIV

研究领域 >> 感染

[参考文献]

[1]. Sadler BM, Stein DS. Clinical pharmacology and pharmacokinetics of amprenavir. Ann Pharmacother. 2002 Jan;36(1):102-18.

[2]. Esposito V, Verdina A, Manente L, Amprenavir inhibits the migration in human hepatocarcinoma cell and the growth of xenografts. J Cell Physiol. 2013 Mar;228(3):640-5.

[3]. Helsley RN, Sui Y, Ai N, Pregnane X Receptor Mediates Dyslipidemia Induced by the HIV Protease Inhibitor Amprenavir in Mice. Mol Pharmacol. 2013 Jun;83(6):1190-9.

[相关活性小分子]

安普那韦物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
722.5±70.0 °C at 760 mmHg

[ 熔点 ]:
72-74ºC

[ 分子式 ]:
C₂₅H₃₅N₃O₆S

[ 分子量 ]:
505.627

[ 闪点 ]:
390.8±35.7 °C

[ 精确质量 ]:
505.224670

[ PSA ]:
139.57000

[ LogP ]:
4.68

[ 外观性状 ]:
灰白色至淡黄色

[ 蒸汽压 ]:
0.0±2.5 mmHg at 25°C

[ 折射率 ]:
1.602

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
DMSO: soluble20mg/mL, clear

安普那韦MSDS

详细MSDS(安全技术说明书)

安普那韦安全信息

[ 危险品运输编码 ]:
3077

[ 海关编码 ]:
2935009090

安普那韦海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

安普那韦文献

A comparison of in vitro ADME properties and pharmacokinetics of azithromycin and selected 15-membered ring macrolides in rodents.

Eur. J. Drug Metab. Pharmacokinet. 39(4) , 263-76, (2014)

The purpose of this study was to evaluate the impact of structural modifications on the 15-membered macrolactone ring and/or substituents on the in vitro ADME properties and in vivo pharmacokinetic (P...

Parallel ultra high pressure liquid chromatography-mass spectrometry for the quantification of HIV protease inhibitors using dried spot sample collection format.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 965 , 244-53, (2014)

An assay was developed and validated for the quantification of eight protease inhibitors (indinavir (IDV), ritonavir (RTV), lopinavir (LPV), saquinavir (SQV), amprenavir (APV), nelfinavir (NFV), ataza...

HZ08 reverse P-glycoprotein mediated multidrug resistance in vitro and in vivo.

PLoS ONE 10(2) , e0116886, (2015)

Multidrug efflux transporter P-glycoprotein (P-gp) is highly expressed on membrane of tumor cells and is implicated in resistance to tumor chemotherapy. HZ08 is synthesized and studied in order to fin...

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