苄脒盐酸盐

苄脒盐酸盐用途

Benzamidine hydrochloride 是一种可逆的,竞争性胰蛋白酶样丝氨酸蛋白酶 (trypsin-like serine proteases) 抑制剂,对 uPA、胰蛋白酶、类胰蛋白酶和 Xa 因子作用的 Ki 值分别为 97 µM, 21 µM, 20 µM 和 110 µM。

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苄脒盐酸盐名称

[ CAS 号 ]:
1670-14-0

[ 中文名 ]:
苄脒盐酸盐

[ 英文名 ]:
Benzimidamide hydrochloride

[中文别名 ]:

[英文别名 ]:

BENZAMIDE HCL H2O
benzenecarboximidamide hydrochloride
EINECS 216-795-4
benzamidinium chloride
benzamidine-hydrochloride
Benzamidine hydrochloride
BENZAMIDINE HCL
2-phenylamidine hydrochloride
Benzenecarboximidamide hydrochloride (1:1)
benzamidine hydroxychloride

苄脒盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> Ser/Thr蛋白酶

研究领域 >> 癌症

[ 靶点 ]

Ki: 97 µM (uPA), 21 µM (trypsin), 20 µM (tryptase), 110 µM (factor Xa)[1]

[体外研究]

盐酸苯甲脒对tPA和凝血酶的抑制作用较弱,Kis分别为750μM和320μM[1]。

[参考文献]

[1]. Tanizawa K, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69(5):893-9.

[2]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312.

苄脒盐酸盐物理化学性质

[ 密度 ]:
1.09 g/cm3

[ 沸点 ]:
332.9ºC at 760 mmHg

[ 熔点 ]:
86-88 °C(lit.)

[ 分子式 ]:
C₇H₉ClN₂

[ 分子量 ]:
156.613

[ 闪点 ]:
155.1ºC

[ 精确质量 ]:
156.045425

[ PSA ]:
49.87000

[ LogP ]:
2.57270

[ 外观性状 ]:
白色至灰白色固体

[ 蒸汽压 ]:
5.63E-05mmHg at 25°C

[ 储存条件 ]:
通风低温干燥

[ 水溶解性 ]:
soluble

苄脒盐酸盐MSDS

苄脒盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV6260000

CHEMICAL NAME :: Benzamidine, hydrochloride

CAS REGISTRY NUMBER :: 1670-14-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H8-N2.Cl-H

MOLECULAR WEIGHT :: 156.63

WISWESSER LINE NOTATION :: ZYR&UM &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 580 mg/kg

TOXIC EFFECTS :: Brain and Coverings - meningeal changes Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 20,1045,1979

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苄脒盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CV6260000

[ 海关编码 ]:
2925290090

苄脒盐酸盐合成路线

苄脒盐酸盐上下游产品

苄脒盐酸盐上游产品

苄脒盐酸盐下游产品

苄脒盐酸盐海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

苄脒盐酸盐文献

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J. Reprod. Immunol. 106 , 100-9, (2014)

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PLoS ONE 9(9) , e107182, (2014)

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