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骨化二醇

骨化二醇用途

Calcifediol(25-hydroxy Vitamin D3)是由维生素D3在肝中经羟基化后得到的前激素。

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骨化二醇名称

[ CAS 号 ]:
19356-17-3

[ 中文名 ]:
骨化二醇

[ 英文名 ]:
Calcifediol

[中文别名 ]:

[英文别名 ]:

Didrogyl
25-hydroxyvitamin D3
Ro 8-8892
25-HCC
U 32070E
Vitamin D3 25 Calcifediol
25-hydroxycholecalciferol
9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-3β,25-DIOL
MFCD00867077
CALCIDIOL

骨化二醇生物活性

[ 描述 ]:

Calcifediol(25-hydroxy Vitamin D3)是由维生素D3在肝中经羟基化后得到的前激素。

[ 相关类别 ]:

信号通路 >> 维生素 D 相关 >> VD/VDR

研究领域 >> 代谢疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

脂质体或乙醇溶液中的Calcifediol对来自假单胞菌感染的鼠上皮细胞的促炎细胞因子KC的释放没有影响。用Calcifediol脂质体治疗感染的人支气管16-HBE细胞导致细菌存活率显着降低[1]。

[参考文献]

[1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22.

[相关活性小分子]

骨化二醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
529.2±33.0 °C at 760 mmHg

[ 熔点 ]:
74-76oC

[ 分子式 ]:
C₂₇H₄₄O₂

[ 分子量 ]:
400.637

[ 闪点 ]:
221.4±20.0 °C

[ 精确质量 ]:
400.334137

[ PSA ]:
40.46000

[ LogP ]:
7.53

[ 外观性状 ]:
白色至灰白色粉末

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.536

[ 储存条件 ]:
−20°C

骨化二醇MSDS

详细MSDS(安全技术说明书)

骨化二醇安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311-H330-H372

[ 警示性声明 ]:
P260-P280-P284-P301 + P310-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R28

[ 安全声明 (欧洲) ]:
28-36/37-45

[ 危险品运输编码 ]:
UN 2811 6

[ WGK德国 ]:
3

[ 包装等级 ]:
Ⅱ

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骨化二醇文献

Silver dopants for targeted and untargeted direct analysis of unsaturated lipids via infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI).

Rapid Commun. Mass Spectrom. 28(22) , 2461-70, (2014)

Unsaturated lipids play a crucial role in cellular processes as signaling factors, membrane building blocks or energy storage molecules. However, adequate mass spectrometry imaging of this diverse gro...

Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.

J. Chromatogr. A. 1364 , 214-22, (2014)

We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of...

Improved analysis of vitamin D metabolites in plasma using liquid chromatography tandem mass spectrometry, and its application to cardiovascular research.

Biomed. Chromatogr. 28(6) , 913-7, (2014)

The accurate and specific measurement of vitamin D is increasingly important for determining the role of vitamin D in the pathogenesis of disease. Liquid chromatography coupled to tandem mass spectrom...

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