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牛磺罗定

牛磺罗定用途

Taurolidine 是一种广谱的抗菌剂 (antimicrobial),用于预防中心静脉导管相关感染。Taurolidine 能通过诱导细胞凋亡 (apoptosis) 对脑肿瘤细胞有直接和选择性的抗肿瘤作用。

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牛磺罗定名称

[ CAS 号 ]:
19388-87-5

[ 中文名 ]:
滔罗林

[ 英文名 ]:
Taurolidine

[中文别名 ]:

[英文别名 ]:

Taurolin
Taurolidine
Tauroline

牛磺罗定生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Haro C, et al. Taurolidine, an antiseptic for the prevention of central venous catheter-related infections. Rev Chilena Infectol. 2019 Aug;36(4):414-420.

[2]. Stendel R, et al. Treatment of glioblastoma with intravenous taurolidine. First clinical experience. Anticancer Res. 2004 Mar-Apr;24(2C):1143-7.

牛磺罗定物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
471.2±55.0 °C at 760 mmHg

[ 熔点 ]:
156ºC

[ 分子式 ]:
C₇H₁₆N₄O₄S₂

[ 分子量 ]:
284.356

[ 闪点 ]:
238.8±31.5 °C

[ 精确质量 ]:
284.061310

[ PSA ]:
115.58000

[ LogP ]:
-2.55

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.564

[ 储存条件 ]:
0-10°C;存放于惰性气体之中;避免光,空气,加热

牛磺罗定MSDS

牛磺罗定安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

牛磺罗定合成路线

牛磺罗定上下游产品

牛磺罗定上游产品

牛磺罗定下游产品

牛磺罗定海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

牛磺罗定文献

Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines.

Int. J. Colorectal Dis. 29(11) , 1339-48, (2014)

The taurine derivative taurolidine (TRD) exerts anti-neoplastic effects in a variety of tumor models. On the other hand, TRD at low doses was shown to reduce cell-cell adhesion, a prerequisite for met...

Central venous catheters and catheter locks in children with cancer: a prospective randomized trial of taurolidine versus heparin.

Pediatr. Blood Cancer 60(8) , 1292-8, (2013)

To determine if the catheter lock taurolidine can reduce the number of catheter-related bloodstream infections (CRBSI) in pediatric cancer patients with tunneled central venous catheters (CVC).During ...

Taurolidine specifically inhibits growth of neuroblastoma cell lines in vitro.

J. Pediatr. Hematol. Oncol. 36(4) , e219-23, (2014)

Neuroblastoma is a common pediatric solid tumor with poor outcome for metastatic disease. Thus, novel therapeutic options are of main interest. The anti-neoplastic properties of taurolidine have been ...

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