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柠檬酸奥索拉明

柠檬酸奥索拉明用途

Oxolamine柠檬酸盐是一种止咳剂。

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柠檬酸奥索拉明名称

[ CAS 号 ]:
1949-20-8

[ 中文名 ]:
柠檬酸奥索拉明

[ 英文名 ]:
Oxolamine (citrate)

[中文别名 ]:

奥索拉明柠檬酸盐

[英文别名 ]:

CITRATO OXOLAMINA
OXOLAMINE CITRATE SALT
oxolamine dihydrogen citrate
OXOLAMINE CITRATE
OxolaminCitrate
Oxolamine (citrate)

柠檬酸奥索拉明生物活性

[ 描述 ]:

Oxolamine柠檬酸盐是一种止咳剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[相关活性小分子]

柠檬酸奥索拉明物理化学性质

[ 密度 ]:
1.066g/cm3

[ 沸点 ]:
364.8ºC at 760 mmHg

[ 熔点 ]:
153-154ºC

[ 分子式 ]:
C₂₀H₂₇N₃O₈

[ 分子量 ]:
437.44400

[ 闪点 ]:
174.4ºC

[ 精确质量 ]:
437.18000

[ PSA ]:
174.29000

[ LogP ]:
1.37240

[ 外观性状 ]:
白色或灰白色结晶粉末

[ 蒸汽压 ]:
1.64E-05mmHg at 25°C

[ 储存条件 ]:
2-8℃

柠檬酸奥索拉明MSDS

详细MSDS(安全技术说明书)

柠檬酸奥索拉明毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RO0720000

CHEMICAL NAME :: 1,2,4-Oxadiazole, 5-(2-(diethylamino)ethyl)-3-phenyl-, citrate

CAS REGISTRY NUMBER :: 1949-20-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H19-N3-O.C6-H8-O7

MOLECULAR WEIGHT :: 437.50

WISWESSER LINE NOTATION :: T5NO DNJ C2N2&2 ER &QV1XQVQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 16,209,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 351 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #683M

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 19,631,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 351 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 16,209,1961 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 43400 mg/kg/7W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in kidney weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: EMPSAL Experimental and Molecular Pathology, Supplement. (New York, NY) No.1-3, 1963-66. Discontinued. Volume(issue)/page/year: 2,1,1963

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 7177 mg/kg/7W-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: EMPSAL Experimental and Molecular Pathology, Supplement. (New York, NY) No.1-3, 1963-66. Discontinued. Volume(issue)/page/year: 2,1,1963 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 gm/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

REFERENCE :: EMPSAL Experimental and Molecular Pathology, Supplement. (New York, NY) No.1-3, 1963-66. Discontinued. Volume(issue)/page/year: 2,1,1963 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 120 mg/kg

SEX/DURATION :: female 9-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,781,1967

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柠檬酸奥索拉明安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
RO0720000

柠檬酸奥索拉明文献

[Therapeutic action of oxolamine in acute tracheo-bronchitis].

Clin. Ter. 100(5) , 485-92, (1982)

Hallucinations in children caused by oxolamine citrate.

Med. J. Aust. 150(8) , 449-50, 452, (1989)

Twenty reports in Australia, Belgium and The Netherlands have implicated oxolamine-citrate cough-mixtures as a cause of hallucinations in children of less than 10 years of age. Fever is not thought to...

Sustained-release dosage form of oxolamine citrate: preparation and release kinetics.

J. Microencapsul. 9(2) , 167-72, (1992)

One of the principal uses of microencapsulation for pharmaceuticals has been the preparation of sustained-release dosage forms which have been usually presented in the form of a suspension or gel. How...

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