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枸櫞酸奧芬那君

枸櫞酸奧芬那君用途

Orphenadrine柠檬酸盐是NMDA受体拮抗剂,Ki为6.0μM,还是HERG钾离子通道阻断剂。

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枸櫞酸奧芬那君名称

[ CAS 号 ]:
4682-36-4

[ 中文名 ]:
柠檬酸邻甲苯海拉明

[ 英文名 ]:
orphenadrine citrate

[中文别名 ]:

[英文别名 ]:

Orphenadrine Citrate
Orphenadrine Citrate Salt
MFCD00079197
EINECS 225-137-5

枸櫞酸奧芬那君生物活性

[ 描述 ]:

Orphenadrine柠檬酸盐是NMDA受体拮抗剂,Ki为6.0μM,还是HERG钾离子通道阻断剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

[参考文献]

[1]. Kornhuber, J., et al., Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect, 1995. 102(3): p. 237-46.

[2]. Pubill, D., et al., Assessment of the adrenergic effects of orphenadrine in rat vas deferens. J Pharm Pharmacol, 1999. 51(3): p. 307-12.

[相关活性小分子]

枸櫞酸奧芬那君物理化学性质

[ 密度 ]:
1.014 g/cm3

[ 沸点 ]:
363ºC at 760 mmHg

[ 熔点 ]:
132-134ºC

[ 分子式 ]:
C₂₄H₃₁NO₈

[ 分子量 ]:
461.50500

[ 闪点 ]:
107.1ºC

[ 精确质量 ]:
461.20500

[ PSA ]:
133.60000

[ LogP ]:
2.75980

[ 外观性状 ]:
白色或近乎于白色,结晶粉末

[ 储存条件 ]:
2-8°C

枸櫞酸奧芬那君MSDS

详细MSDS(安全技术说明书)

枸櫞酸奧芬那君安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H351

[ 警示性声明 ]:
P281

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R22;R40

[ 安全声明 (欧洲) ]:
S22-S36

[ 危险品运输编码 ]:
UN 3249

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

枸櫞酸奧芬那君文献

Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs.

Exp. Neurol. 255 , 96-102, (2014)

Although the sodium channel blocker mexiletine is considered the first-line drug in myotonia, some patients experiment adverse effects, while others do not gain any benefit. Other antimyotonic drugs a...

Spectrophotometric determination of tizanidine and orphenadrine via ion pair complex formation using eosin Y.

Chem. Cent. J. 5 , 60, (2011)

A simple, sensitive and rapid spectrophotometric method was developed and validated for the determination of two skeletal muscle relaxants namely, tizanidine hydrochloride (I) and orphenadrine citrate...

Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study.

Audiol. Neurootol. 17(3) , 179-88, (2012)

Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharma...

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枸櫞酸奧芬那君

枸櫞酸奧芬那君用途

枸櫞酸奧芬那君名称

枸櫞酸奧芬那君生物活性

枸櫞酸奧芬那君物理化学性质

枸櫞酸奧芬那君MSDS

详细MSDS(安全技术说明书)

枸櫞酸奧芬那君安全信息

枸櫞酸奧芬那君文献

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