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草酸右旋西酞普兰

草酸右旋西酞普兰用途

Escitalopram是选择性5羟色胺重吸收抑制剂(SSRI),Ki为0.89 nM。

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草酸右旋西酞普兰名称

[ CAS 号 ]:
219861-08-2

[ 中文名 ]:
草酸右旋西酞普兰

[ 英文名 ]:
Escitalopram oxalate

[中文别名 ]:

[英文别名 ]:

Lexapro (TN)
MFCD06407826
Lu-26-054-0
ESCIFALOPRAMOXALATE
(S)-Citalopram Oxalate
Escitalopram oxalate (USAN)
Lexapro
escitalopram oxalic acid
Escitalopram Oxalate
Cipralex

草酸右旋西酞普兰生物活性

[ 描述 ]:

Escitalopram是选择性5羟色胺重吸收抑制剂(SSRI),Ki为0.89 nM。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白

研究领域 >> 神经疾病

[参考文献]

[1]. Zhang, P., et al., Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbon itrile) analogues at monoamine transporters. J Med Chem, 2010. 53(16): p. 6112-21.

[2]. Pastoor, D. and J. Gobburu, Clinical pharmacology review of escitalopram for the treatment of depression. Expert Opin Drug Metab Toxicol, 2014. 10(1): p. 121-8.

[相关活性小分子]

草酸右旋西酞普兰物理化学性质

[ 沸点 ]:
428.3ºC at 760 mmHg

[ 熔点 ]:
152-153ºC

[ 分子式 ]:
C₂₂H₂₃FN₂O₅

[ 分子量 ]:
414.427

[ 闪点 ]:
212.8ºC

[ 精确质量 ]:
414.159088

[ PSA ]:
110.86000

[ LogP ]:
2.96858

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
-20°C Freezer, Under Inert Atmosphere

草酸右旋西酞普兰MSDS

详细MSDS(安全技术说明书)

草酸右旋西酞普兰安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

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草酸右旋西酞普兰文献

The effect of combined treatment with risperidone and antidepressants on the MK-801-induced deficits in the social interaction test in rats.

Pharmacol. Rep. 67 , 1183-7, (2015)

Several clinical reports have suggested that augmentation of atypical antipsychotics' activity by antidepressants may efficiently improve the treatment of negative and some cognitive symptoms of schiz...

Prolonged administration of antidepressant drugs leads to increased binding of [(3)H]MPEP to mGlu5 receptors.

Neuropharmacology 84 , 46-51, (2014)

Metabotropic glutamate 5 (mGlu5) receptors are functionally connected with NMDA receptors. The antidepressant activity of the NMDA receptor antagonist ketamine in both preclinical and clinical studies...

Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats.

Neuropharmacology 97 , 251-8, (2015)

Depression during pregnancy has been linked to in utero stress and is associated with long-lasting symptoms in offspring, including anxiety, helplessness, attentional deficits, and social withdrawal. ...

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2019-01-09 16:35:23

导读：草酸艾司西酞普兰，别名草酸右旋西酞普兰。它是目前一线的抗抑郁药就是5-羟色胺再摄取抑制剂（SSRIs）类药物。抗抑郁药与兴奋药不同，它只能使抑郁病人的抑郁症状消除，而不会使正常人的情绪提高。而草酸艾司西酞普兰的作用原理也是类似，它通过调整脑内某些化学物质的浓度，可以减轻患者的焦虑和烦躁症状，...