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文拉法辛盐酸盐

文拉法辛盐酸盐用途

Venlafaxine盐酸盐是5-羟色胺和去甲肾上腺素重吸收抑制剂(SNRI)。

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文拉法辛盐酸盐名称

[ CAS 号 ]:
99300-78-4

[ 中文名 ]:
盐酸文拉法辛

[ 英文名 ]:
Venlafaxine hydrochloride

[中文别名 ]:

[英文别名 ]:

Efectin
Venlafaxine Hydrochloride
Effexor
Venlafaxine HCl
MFCD03658865
EINECS 200-659-6
Efexor
RTECS GV8872760

文拉法辛盐酸盐生物活性

[ 描述 ]:

Venlafaxine盐酸盐是5-羟色胺和去甲肾上腺素重吸收抑制剂(SNRI)。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白

研究领域 >> 神经疾病

[参考文献]

[1]. Bymaster FP, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.

[2]. Goeringer KE, et al. Postmortem tissue concentrations of venlafaxine. Forensic Sci Int. 2001 Sep 15;121(1-2):70-5.

[相关活性小分子]

文拉法辛盐酸盐物理化学性质

[ 密度 ]:
1.394 g/cm3

[ 沸点 ]:
397.6ºC at 760 mmHg

[ 熔点 ]:
207-209ºC

[ 分子式 ]:
C₁₇H₂₈ClNO₂

[ 分子量 ]:
313.863

[ 闪点 ]:
194.2ºC

[ 精确质量 ]:
313.180847

[ PSA ]:
32.70000

[ LogP ]:
3.83760

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
可溶于：甲醇

文拉法辛盐酸盐MSDS

文拉法辛盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GV8872760

CHEMICAL NAME :: Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, hydrochloride

CAS REGISTRY NUMBER :: 99300-78-4

LAST UPDATED :: 199801

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H27-N-O2.Cl-H

MOLECULAR WEIGHT :: 313.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 235 mg/kg/12D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - other changes

REFERENCE :: JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977- Volume(issue)/page/year: 20,266,1996

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文拉法辛盐酸盐安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-37/39

[ 危险品运输编码 ]:
1230.0

[ RTECS号 ]:
GV8872760

[ 危险类别 ]:
3、6.1

[ 海关编码 ]:
2922509090

文拉法辛盐酸盐合成路线

文拉法辛盐酸盐上下游产品

文拉法辛盐酸盐上游产品

文拉法辛盐酸盐下游产品

文拉法辛盐酸盐海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

文拉法辛盐酸盐文献

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J. Chromatogr. A. 1418 , 140-9, (2015)

The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of...

The antidepressant venlafaxine disrupts brain monoamine levels and neuroendocrine responses to stress in rainbow trout.

Environ. Sci. Technol. 48(22) , 13434-42, (2014)

Venlafaxine, a serotonin-norepinephrine reuptake inhibitor, is a widely prescribed antidepressant drug routinely detected in the aquatic environment. However, little is known about its impact on the p...

Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry.

J. Chromatogr. A. 1363 , 226-235, (2014)

The interest for environmental fate assessment of chiral pharmaceuticals is increasing and enantioselective analytical methods are mandatory. This study presents an enantioselective analytical method ...

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