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苯并[c]吖啶

苯并[c]吖啶名称

[ CAS 号 ]:
225-51-4

[ 中文名 ]:
苯并[c]吖啶

[ 英文名 ]:
BENZ(C)ACRIDINE

[中文别名 ]:

苯并(c)吖啶

[英文别名 ]:

3,4-Benzacridine
Benzo[c]acridine
3,4-Benzoacridine
BENZ(C)ACRIDINE
12-Azabenz[a]anthracene
Benz[c]acridine
7,8-Benzacridine

苯并[c]吖啶物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
446.2±14.0 °C at 760 mmHg

[ 熔点 ]:
132°C

[ 分子式 ]:
C₁₇H₁₁N

[ 分子量 ]:
229.276

[ 闪点 ]:
201.4±12.7 °C

[ 精确质量 ]:
229.089142

[ PSA ]:
12.89000

[ LogP ]:
4.63

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.783

[ 储存条件 ]:
通风低温干燥

苯并[c]吖啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CU2975000

CHEMICAL NAME :: Benz(c)acridine

CAS REGISTRY NUMBER :: 225-51-4

BEILSTEIN REFERENCE NO. :: 0154999

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C17-H11-N

MOLECULAR WEIGHT :: 229.29

WISWESSER LINE NOTATION :: T D6 B666 CNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 mg/kg/67W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9630 mg/kg/3D-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,103,1983 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,129,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,129,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

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苯并[c]吖啶安全信息

[ 危险品运输编码 ]:
UN 2811

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933990090

苯并[c]吖啶合成路线

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苯并[c]吖啶上游产品

苯并[c]吖啶下游产品

苯并[c]吖啶海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

苯并[c]吖啶文献

Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons.

Bioorg. Med. Chem. 8(5) , 1171-82, (2000)

Coralyne and several other synthetic benzo[a,g]quinolizium derivatives related to protoberberine alkaloids have exhibited activity as topoisomerase poisons. These compounds are characterized by the pr...

Heteroatom effects in chemical carcinogenesis: effects of ring heteroatoms on ease of carbocation formation.

Cancer Biochem. Biophys. 7(1) , 53-60, (1983)

The presence of a heteroatom can influence the ease with which a PAH diol-epoxide forms a triol carbocation. The influence of the heteroatom should be greatest when it is located where the PAH undergo...

Differentiated genotoxic response of carcinogenic and non-carcinogenic benzacridines and metabolites in rat hepatoma cells.

Carcinogenesis 6(3) , 455-7, (1985)

Two closely related hepatoma cell lines were examined for their genotoxic response to benacridines and their metabolites by the appearance of alkaline labile DNA sites: H5, a dedifferentiated line exp...

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