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盐酸氟喷己醇(盐酸氟哌噻吨)

盐酸氟喷己醇(盐酸氟哌噻吨)用途

Flupentixol dihydrochlorid,一种噻克西酮类药物,可用于精神分裂症以及抗焦虑和抑郁障碍的治疗。

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盐酸氟喷己醇(盐酸氟哌噻吨)名称

[ CAS 号 ]:
2413-38-9

[ 中文名 ]:
盐酸氟哌噻吨

[ 英文名 ]:
Fupentixol dihydrochloride

[中文别名 ]:

二盐酸氟哌噻吨

[英文别名 ]:

FUPENTIXOL DIHYDROCHLORIDE
FLUPENTIXOL DIHYDROCHLORIDE
Fluanxol dihydrochloride
EINECS 219-321-4
Zimelidine dihydrochloride
Fupentixol HCl
flupentixolhydrochloride
fx703

盐酸氟喷己醇(盐酸氟哌噻吨)生物活性

[ 描述 ]:

Flupentixol dihydrochlorid,一种噻克西酮类药物,可用于精神分裂症以及抗焦虑和抑郁障碍的治疗。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Yonar D, et al. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun;198:61-71.

[相关活性小分子]

盐酸氟喷己醇(盐酸氟哌噻吨)物理化学性质

[ 沸点 ]:
554.7ºC at 760 mmHg

[ 分子式 ]:
C₂₃H₂₇Cl₂F₃N₂OS

[ 分子量 ]:
507.440

[ 闪点 ]:
289.3ºC

[ 精确质量 ]:
506.117310

[ PSA ]:
52.01000

[ LogP ]:
6.08150

[ 外观性状 ]:
白色或灰白色固体

[ 蒸汽压 ]:
3.87E-13mmHg at 25°C

[ 储存条件 ]:
Desiccate at RT

[ 水溶解性 ]:
H2O: soluble | soluble

盐酸氟喷己醇(盐酸氟哌噻吨)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XO0740000

CHEMICAL NAME :: Thioxanthene, 9-(3-(4-(2-hydroxyethyl)piperazinyl)propylidene)-2-tr ifluoromethyl-, dihydrochloride

CAS REGISTRY NUMBER :: 2413-38-9

LAST UPDATED :: 199706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C23-H25-F3-N2-O-S.2Cl-H

MOLECULAR WEIGHT :: 507.48

WISWESSER LINE NOTATION :: T C666 BS IYJ FXFFF IU3- DT6M DNTJ C2Q &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 791 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,704,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 258 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 423 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 425 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 94 mg/kg

TOXIC EFFECTS :: Behavioral - sleep

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,87,1962

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盐酸氟喷己醇(盐酸氟哌噻吨)安全信息

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S36/37/39

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
TL9900000

[ 海关编码 ]:
2942000000

盐酸氟喷己醇(盐酸氟哌噻吨)海关

[ 海关编码 ]: 2942000000

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