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盐酸左布比卡因

盐酸左布比卡因用途

盐酸左布比卡因(Levobupivacaine Hcl)是一局部麻醉用化合物。

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盐酸左布比卡因名称

[ CAS 号 ]:
27262-48-2

[ 中文名 ]:
盐酸左布比卡因

[ 英文名 ]:
Levobupivacaine hydrochloride

[中文别名 ]:

[英文别名 ]:

levobupivacaine monohydrochloride
Levobupivacainehydrochloride
(S)-(-)-BUPIVACAINE HCL
Levobupivacaine Hydrochloride
L-BUPIVACAINE HYDROCHLORIDE
L-(-)-Bupivacaine
(S)-Bupivacaine hydrochloride
(RS)-bupivacaine hydrochloride
BUPIVACAINE HCL
Levobupivacaine HCl

盐酸左布比卡因生物活性

[ 描述 ]:

盐酸左布比卡因(Levobupivacaine Hcl)是一局部麻醉用化合物。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 代谢酶/蛋白酶 >> 磷脂

研究领域 >> 其他

[参考文献]

[1]. Burlacu CL, et al. Update on local anesthetics: focus on levobupivacaine. Ther Clin Risk Manag. 2008 Apr;4(2):381-92.

[2]. Gulec D, et al. Intrathecal bupivacaine or levobupivacaine: which should be used for elderly patients? J Int Med Res. 2014 Apr;42(2):376-85.

[相关活性小分子]

U型73122 | D609 钾盐 | 达普拉缔 | 喹吖因二盐酸 | FIPI | 蜂毒肽 | 伐瑞拉迪 | CAY10650 | AA26-9 | ML348 | 丹参酮I | MAFP | ML349 | 1-单壬烷-rac-甘油 | Lp-PLA2-IN-1

盐酸左布比卡因物理化学性质

[ 沸点 ]:
423.4ºC at 760 mmHg

[ 熔点 ]:
254 °C (dec.)(lit.)

[ 分子式 ]:
C₁₈H₂₉ClN₂O

[ 分子量 ]:
324.889

[ 闪点 ]:
209.9ºC

[ 精确质量 ]:
324.196838

[ PSA ]:
23.55000

[ LogP ]:
4.74080

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
2.24E-07mmHg at 25°C

[ 储存条件 ]:
室温，密封

盐酸左布比卡因MSDS

详细MSDS(安全技术说明书)

盐酸左布比卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK6120000

CHEMICAL NAME :: 2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride, (-)-

CAS REGISTRY NUMBER :: 27262-48-2

LAST UPDATED :: 198209

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C18-H28-N2-O.Cl-H

MOLECULAR WEIGHT :: 324.94

WISWESSER LINE NOTATION :: T6NTJ A4 BVMR B1 F1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 207 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

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盐酸左布比卡因安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
T+: Very toxic;Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S22-S36/37/39-S45-S36/37-S53

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
TK6125000

[ 海关编码 ]:
2942000000

盐酸左布比卡因海关

[ 海关编码 ]: 2942000000