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异甜菊醇

异甜菊醇用途

异甜菊醇是一种常见的天然甜味剂，属于四环二萜糖苷。 药理研究表明，甜菊甙及其水解产物，甜菊醇，异甜菊醇和甜菊双糖苷，具有降血糖，降血压，抗炎，抗肿瘤，抗腹泻，抗菌，免疫调节等多种生物活性。
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异甜菊醇名称

[ CAS 号 ]:
27975-19-5

[ 中文名 ]:
异甜菊醇

[ 英文名 ]:
Isosteviol

[中文别名 ]:

[英文别名 ]:

异甜菊醇生物活性

[ 描述 ]:

异甜菊醇(Isosteviol)是甜菊糖的衍生物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 心血管疾病
天然产物 >> 萜类化合物和糖苷

[参考文献]

[1]. Wong KL, et al. Isosteviol acts on potassium channels to relax isolated aortic strips of Wistar rat. Life Sci. 2004 Mar 26;74(19):2379-87.

[2]. Wong KL, et al. Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells. Planta Med. 2004 Feb;70(2):108-12.

[3]. Wong KL, et al. Antiproliferative effect of isosteviol on angiotensin-II-treated rat aortic smooth muscle cells. Pharmacology. 2006;76(4):163-9.


[相关活性小分子]

磺丁基-β-环糊精钠盐 | 环孢霉素A | 2-(3,6-二乙酰氧基-2,7-二氯-9H-氧杂蒽-9-基)苯甲酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | GW4869 | 乙莫克舍 | (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫代双(4-(4-(3-氟苯基)-1H-1,-1H-1,2,3-三唑-1-基)-2-(羟甲基)四氢-2H-吡喃-3,5-二醇) | Mitoquinone甲磺酸盐 | GSK2795039 | CBIC2 | BAPTA-AM | AP20187 | GKT137831 | D-(-)-荧光素 | 单响尾蛇毒蛋白

异甜菊醇物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
455.6±38.0 °C at 760 mmHg

[ 熔点 ]:
228.0 to 232.0 °C

[ 分子式 ]:
C20H30O3

[ 分子量 ]:
318.450

[ 闪点 ]:
243.5±23.3 °C

[ 精确质量 ]:
318.219482

[ PSA ]:
54.37000

[ LogP ]:
4.13

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.551

[ 储存条件 ]:
-20°C

异甜菊醇MSDS

详细MSDS(安全技术说明书)

异甜菊醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RC5532500
CHEMICAL NAME :
17-Norkauran-18-oic acid, 13-methyl-16-oxo-, (4-alpha,8-beta,13-beta)-
CAS REGISTRY NUMBER :
27975-19-5
LAST UPDATED :
199703
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C20-H30-O3
MOLECULAR WEIGHT :
318.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986- Volume(issue)/page/year: 8,33,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
671 mg/kg
TOXIC EFFECTS :
Vascular - regional or general arteriolar or venous dilation Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986- Volume(issue)/page/year: 8,33,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
503 mg/kg
TOXIC EFFECTS :
Vascular - regional or general arteriolar or venous dilation Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986- Volume(issue)/page/year: 8,33,1994
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5060 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986- Volume(issue)/page/year: 8,33,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1070 mg/kg
TOXIC EFFECTS :
Vascular - regional or general arteriolar or venous dilation Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986- Volume(issue)/page/year: 8,33,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
612 mg/kg
TOXIC EFFECTS :
Vascular - regional or general arteriolar or venous dilation Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986- Volume(issue)/page/year: 8,33,1994
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异甜菊醇安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

异甜菊醇合成路线

详细合成路线

异甜菊醇上下游产品

异甜菊醇上游产品

异甜菊醇下游产品

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：异甜菊醇

公司名：云南西力生物技术股份有限公司

区域：昆明市盘龙区

价格：
￥需询单/5mg

联系人：郑雪平

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥298.0/20mg

联系人：刘佳

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公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Isosteviol

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥1111.0/5mg

联系人：李先生

产品详情：异甜菊醇

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相关化合物

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