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10-脱乙酰基巴卡丁 III； 10-去乙酰基巴卡亭

用途

10-Deacetylbaccatin-III是紫杉醇制备过程中的中间体。

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名称

[ CAS 号 ]:
32981-86-5

[ 中文名 ]:
10-脱乙酰基巴卡丁 III

[ 英文名 ]:
10-Deacetylbaccatin III

[中文别名 ]:

[英文别名 ]:

10-Dab
10-DAB (10-Deacetylbaccatin)
MFCD00132913
EINECS 418-680-6
10-Deacetylbaccatine
10-deacetylbaccatin11
10-DAB-III
10DBA III
10-Deacetyl
10-DEACETYLBACCATIN

生物活性

[ 描述 ]:

10-Deacetylbaccatin-III是紫杉醇制备过程中的中间体。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

[参考文献]

[1]. Li S, Zhang P, Zhang M, Fu C, Yu L. Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene in Taxus chinensis. Plant Biol (Stuttg). 2013 Jan;15(1):19-26.

[2]. Naill MC, Kolewe ME, Roberts SC. Paclitaxel uptake and transport in Taxus cell suspension cultures. Biochem Eng J. 2012 Apr 15;63:50-56.

[3]. Qayum M, Nisar M, Shah MR, et al. Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc. Phytother Res. 2012 Apr;26(4):552-6.

[4]. Kevin Walker and Rodney Croteau. Taxol biosynthesis: Molecular cloning of a benzoyl- CoA:taxane 2α-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli. PNAS, 2000 , 97（25）：13591-13596.

[相关活性小分子]

物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
716.8±60.0 °C at 760 mmHg

[ 熔点 ]:
231-236 °C

[ 分子式 ]:
C₂₉H₃₆O₁₀

[ 分子量 ]:
544.590

[ 闪点 ]:
233.5±26.4 °C

[ 精确质量 ]:
544.230835

[ PSA ]:
159.82000

[ LogP ]:
3.51

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.624

[ 储存条件 ]:
0-10°C;避免加热

[ 水溶解性 ]:
INSOLUBLE

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S45-S38-S36/37/39-S28A

[ 危险品运输编码 ]:
1544

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

合成路线

详细合成路线

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文献

Disposition of [G-(3)H]paclitaxel and cremophor EL in a patient with severely impaired renal function.

Drug Metab. Dispos. 27 , 1300, (1999)

In the present work, we studied the pharmacokinetics and metabolic disposition of [G-(3)H]paclitaxel in a female patient with recurrent ovarian cancer and severe renal impairment (creatinine clearance...

Molecular mechanisms of patupilone resistance.

Cancer Res. 68 , 10197-10204, (2008)

Patupilone is an epothilone in advanced clinical development that has shown promising efficacy in heavily pretreated patients. This study aimed at characterizing the mechanisms of patupilone activity ...

Taxol biosynthesis: Molecular cloning of a benzoyl- CoA:taxane 2-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli Kevin Walker and Rodney Croteau PNAS

Proc. 10th Am. Peptide Symp 97 , 13591-13596, (2000)

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