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A1受体促进剂,CHA

A1受体促进剂,CHA用途

N6-Cyclohexyladenosine是一种选择性的腺苷A1 受体激动剂 (EC50 = 8.2 nM)。

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A1受体促进剂,CHA名称

[ CAS 号 ]:
36396-99-3

[ 中文名 ]:
A1受体促进剂,CHA

[ 英文名 ]:
N6-Cyclohexyladenosine

[中文别名 ]:

[英文别名 ]:

N6-Cyclohexyladenosine

A1受体促进剂,CHA生物活性

[ 描述 ]:

N6-Cyclohexyladenosine是一种选择性的腺苷A1 受体激动剂 (EC50 = 8.2 nM)。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

研究领域 >> 神经疾病

[参考文献]

[1]. Asghari AA, et al. Adenosine A1 receptor agonist, N6-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies. J Neurol Sci. 2013 Feb 15;3

[相关活性小分子]

A1受体促进剂,CHA物理化学性质

[ 密度 ]:
1.71g/cm3

[ 沸点 ]:
675.2ºC at 760mmHg

[ 分子式 ]:
C₁₆H₂₃N₅O₄

[ 分子量 ]:
349.38500

[ 闪点 ]:
362.1ºC

[ 精确质量 ]:
349.17500

[ PSA ]:
125.55000

[ LogP ]:
0.25540

[ 折射率 ]:
1.787

[ 储存条件 ]:
2-8℃

A1受体促进剂,CHAMSDS

详细MSDS(安全技术说明书)

A1受体促进剂,CHA安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

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A1受体促进剂,CHA文献

An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat.

Neuropharmacology 97 , 160-70, (2015)

Adenosine kinase (AK) inhibitor is a potential candidate for controlling pain, but some AK inhibitors have problems of adverse effects such as motor impairment. ABT-702, a non-nucleoside AK inhibitor,...

IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection.

Biochem. Biophys. Res. Commun. 449(4) , 477-82, (2014)

Several diseases are related to retinal ganglion cell death, such as glaucoma, diabetes and other retinopathies. Many studies have attempted to identify factors that could increase neuroprotection aft...

The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice.

Neuropharmacology 72 , 1-8, (2013)

Adenosine agonists or low doses of morphine exert anti-convulsant effects in different models of seizures. On the other hand, a tight interaction has been reported between morphine and adenosine in va...

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