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鼠尾草酸

鼠尾草酸用途

Carnosic acid 能够抑制氧化应激和炎症,抑制细胞增殖,并拥有抗菌活性。

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鼠尾草酸名称

[ CAS 号 ]:
3650-09-7

[ 中文名 ]:
鼠尾草酸

[ 英文名 ]:
Carnosic acid

[英文别名 ]:

Salvin
Carnosic acid
RoseOx
11,12-Dihydroxyabieta-8,11,13-trien-20-oic acid
Carnosic acid
MFCD02259459
Carsonic acid
Carnosolic Acid

鼠尾草酸生物活性

[ 描述 ]:

Carnosic acid 能够抑制氧化应激和炎症,抑制细胞增殖,并拥有抗菌活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

研究领域 >> 癌症

天然产物 >> 萜类化合物和糖苷

[体外研究]

鼠尾草酸(一种酚二萜)富含于唇形科植物的叶子中,并且在迷迭香(Rosmarinus officinalis L.)和鼠尾草(Salvia officinalis)的干燥叶中特别高。已经证实,鼠尾草酸可抑制氧化应激和炎症,抑制细胞增殖和抗菌活性。广泛报道,鼠尾草酸在不同类型的癌症中具有治疗潜力,主要基于体外实验。在神经退行性疾病的实验模型中,鼠尾草酸也显示出神经保护作用,主要是通过激活抗氧化剂NRF2/ARE途径[1]。

[参考文献]

[1]. Yesil-Celiktas O, et al. Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods Hum Nutr. 2010 Jun;65(2):158-63.

[相关活性小分子]

鼠尾草酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
506.4±50.0 °C at 760 mmHg

[ 熔点 ]:
190 °C

[ 分子式 ]:
C₂₀H₂₈O₄

[ 分子量 ]:
332.434

[ 闪点 ]:
274.2±26.6 °C

[ 精确质量 ]:
332.198761

[ PSA ]:
77.76000

[ LogP ]:
4.93

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.576

[ 储存条件 ]:
−20°C

鼠尾草酸MSDS

详细MSDS(安全技术说明书)

鼠尾草酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

鼠尾草酸合成路线

详细合成路线

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鼠尾草酸文献

Redox-dependent induction of antioxidant defenses by phenolic diterpenes confers stress tolerance in normal human skin fibroblasts: Insights on replicative senescence.

Free Radic. Biol. Med. 83 , 262-72, (2015)

Mild stress-induced hormesis represents a promising strategy for targeting the age-related accumulation of molecular damage and, therefore, for preventing diseases and achieving healthy aging. Fruits,...

Carnosol Is a Potent Lung Protective Agent: Experimental Study on Mice.

Transplant. Proc. 47 , 1657-61, (2015)

Oxidative stress has been implicated in various disease states and ischemia/reperfusion injury is a direct consequence of oxidative stress in lung transplantation. Because the success rate of organ tr...

Enhanced Eryptosis Following Exposure to Carnosic Acid.

Cell Physiol. Biochem. 37 , 1779-91, (2015)

The phenolic abietane diterpene component of rosemary and sage, carnosic acid, may either induce or inhibit apoptosis of nucleated cells. The mechanisms involved in the effects of carnosic acid includ...

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