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酒石酸伐伦克林

酒石酸伐伦克林名称

[ CAS 号 ]:
375815-87-5

[ 中文名 ]:
酒石酸伐仑克林

[ 英文名 ]:
Varenicline Tartrate

[中文别名 ]:

[英文别名 ]:

Chantix
Champix
Varenicline tartrate

酒石酸伐伦克林生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 胆碱受体

信号通路 >> 神经信号通路 >> 胆碱受体

研究领域 >> 神经疾病

天然产物 >> 其他

[参考文献]

[1]. Krebs P, Sherman SE. Review: Varenicline for tobacco cessation does not increase CV serious adverse events. Ann Intern Med. 2012 Aug 21;157(4):JC2-2.

[2]. Kikkawa, H.; Maruyama, N.; Fujimoto, Y.; Hasunuma, T. Single- and multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy Japanese adult smokers. Journal of Clinical Pharmacology (2011), 51(4), 527-537.

[3]. Pachas GN, Cather C, Pratt SA et al. Varenicline for Smoking Cessation in Schizophrenia: Safety and Effectiveness in a 12-Week, Open-Label Trial. J Dual Diagn. 2012;8(2):117-125.

[4]. Bordia T, Hrachova M, Chin M et al. Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum. J Pharmacol Exp Ther. 2012 Aug;342(2):327-34.

[5]. Varenicline

[相关活性小分子]

酒石酸伐伦克林物理化学性质

[ 沸点 ]:
400.6ºC at 760 mmHg

[ 熔点 ]:
206-208ºC

[ 分子式 ]:
C₁₇H₁₉N₃O₆

[ 分子量 ]:
361.35

[ PSA ]:
23.79000

[ LogP ]:
4.49528

[ 外观性状 ]:
黄褐色固体

[ 储存条件 ]:
Desiccate at RT

[ 水溶解性 ]:
DMSO: >5mg/mL

酒石酸伐伦克林MSDS

详细MSDS(安全技术说明书)

酒石酸伐伦克林安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危害码 (欧洲) ]:
Xn,N,T,F

[ 风险声明 (欧洲) ]:
22-50-39/23/24/25-23/24/25-11

[ 安全声明 (欧洲) ]:
22-57-45-36/37-16-7

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

酒石酸伐伦克林合成路线

详细合成路线

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酒石酸伐伦克林文献

Concurrent access to nicotine and sucrose in rats.

Psychopharmacol. Ser. 232(8) , 1451-60, (2015)

Animal models that allow concurrent access to drug and nondrug reinforcers provide unique insight into the etiology, maintenance, and treatment of drug use.We sought to develop and utilize a concurren...

Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.

Neuropharmacology 99 , 142-55, (2015)

Chronic treatment with nicotine is known to increase the α4β2-nAChR sites in brain, to decrease α6β2-nAChR sites and to have minimal effect on α3β4-and α7-nAChR populations. Varenicline is now used as...

Effects of varenicline on ethanol-induced conditioned place preference, locomotor stimulation, and sensitization.

Alcohol. Clin. Exp. Res. 38(12) , 3033-42, (2015)

Varenicline, a partial nicotinic acetylcholine receptor (nAChR) agonist, is a promising new drug for the treatment of alcohol (ethanol [EtOH]) dependence. Varenicline has been approved by the Food and...

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