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PFK-015

PFK-015用途

PFK-015是PFKFB3抑制剂,对重组PFKFB3的IC50为110 nM,能抑制肿瘤细胞内PFKFB3活性,IC50为20 nM。

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PFK-015名称

[ CAS 号 ]:
4382-63-2

[ 中文名 ]:
PFK-015

[ 英文名 ]:
PFK-015

[英文别名 ]:

1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
PFK-015

PFK-015生物活性

[ 描述 ]:

PFK-015是PFKFB3抑制剂,对重组PFKFB3的IC50为110 nM,能抑制肿瘤细胞内PFKFB3活性,IC50为20 nM。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

[参考文献]

[1]. Pfkfb3 inhibitor and methods of use as an anti-cancer therapeutic

[2]. Brian Clem, et al. Abstract 2825: Characterization of a novel small molecule antagonist of 6-phosphofructo-2-kinase that suppresses glucose metabolism and tumor growth. Cancer Research: April 15, 2011; Volume 71, Issue 8, Supplement 1

[相关活性小分子]

PFK-015物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
464.4±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₇H₁₂N₂O

[ 分子量 ]:
260.290

[ 闪点 ]:
233.5±35.1 °C

[ 精确质量 ]:
260.094971

[ PSA ]:
42.85000

[ LogP ]:
2.62

[ 外观性状 ]:
白色至米色粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.698

[ 储存条件 ]:
-20℃

PFK-015安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危险品运输编码 ]:
NONH for all modes of transport

PFK-015文献

Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells.

Cell Death Dis. 6 , e2005, (2015)

Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. However, the underlying mechanism of the regulatory role in autophagy initiated by rasfonin is largely unknown. Moreover,...

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