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菜油甾醇

菜油甾醇用途

Campesterol是一种植物甾醇,具有降胆固醇和抗癌作用。

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菜油甾醇名称

[ CAS 号 ]:
474-62-4

[ 中文名 ]:
菜油甾醇

[ 英文名 ]:
Campesterol

[中文别名 ]:

[英文别名 ]:

Ergost-5-en-3β-ol, (24R)-
(24R)-Ergost-5-en-3b-ol
(24R)-5-Ergosten-3β-ol
EINECS 207-484-4
(3β,24R)-Ergost-5-en-3-ol
(24R)-5-Ergosten-3-β-ol
(3b,24R)-Ergost-5-en-3-ol
MFCD00010475
(24R)-Ergost-5-en-3β-ol
(24R)-5-Ergosten-3b-ol

菜油甾醇生物活性

[ 描述 ]:

Campesterol是一种植物甾醇,具有降胆固醇和抗癌作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 类固醇

研究领域 >> 癌症

[体外研究]

菜油甾醇在非增殖的人脐静脉内皮细胞(HUVEC)中显示出弱的细胞毒性。在非细胞毒性浓度范围内,菜油甾醇以浓度依赖性方式显着抑制bFGF诱导的HUVEC增殖和管形成,而它不影响HUVEC的运动性。 50μg/ mL的菜油甾醇使细胞活力降低至对照的约56％(IC50超过50μg/ mL)[1]。

[体内研究]

Campesterol有效地破坏体内鸡胚绒毛尿囊膜(CAM)中bFGF诱导的新血管形成[1]。

[细胞实验]

通过XTT测定评估菜油甾醇对活细胞数的影响。用不同浓度（10,20,30,40和50μg/ mL）的菜油甾醇处理HUVEC，并在37℃下在潮湿的培养箱中孵育24小时，向每个孔中加入XTT工作溶液。将细胞在37℃下孵育2小时，并使用酶标仪在450nm处测量光密度[1]。

[参考文献]

[1]. Choi JM, et al. Identification of campesterol from Chrysanthemum coronarium L. and its antiangiogenic activities. Phytother Res. 2007 Oct;21(10):954-9.

[相关活性小分子]

菜油甾醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
489.5±14.0 °C at 760 mmHg

[ 熔点 ]:
156-160ºC

[ 分子式 ]:
C₂₈H₄₈O

[ 分子量 ]:
400.680

[ 闪点 ]:
214.3±12.4 °C

[ 精确质量 ]:
400.370514

[ PSA ]:
20.23000

[ LogP ]:
10.20

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.522

[ 储存条件 ]:
-20°C

菜油甾醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H315-H319-H332-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;T: Toxic;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
26-36-45-36/37/39-23

[ 危险品运输编码 ]:
UN 1888 6.1/PG 3

菜油甾醇合成路线

详细合成路线

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菜油甾醇制备

1. 烟草：FC，32；FC，41， 43；FC，8。

2. 从丙酮中结晶。

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菜油甾醇文献

Phytochemical Characterization of Veronica officinalis L., V. teucrium L. and V. orchidea Crantz from Romania and Their Antioxidant and Antimicrobial Properties.

Int. J. Mol. Sci. 16 , 21109-27, (2015)

Aerial parts of Veronica species are used in Romanian traditional medicine for the treatment of various conditions like kidney diseases, cough, and catarrh, and are known for their wound-healing prope...

Sterol Composition in Infant Formulas and Estimated Intake.

J. Agric. Food Chem. 63 , 7245-51, (2015)

Sterol contents in infant formulas (IFs) from the European market were determined, and their intakes by infants between 0 and 6 months were evaluated. Total animal sterols (mg/100 mL) ranged from 1.71...

On-line liquid chromatography-gas chromatography: A novel approach for the analysis of phytosterol oxidation products in enriched foods.

J. Chromatogr. A. 1396 , 98-108, (2015)

A novel methodology for the automated qualitative and quantitative determination of phytosterol oxidation products in enriched foods via on-line liquid chromatography-gas chromatography (LC-GC) was es...

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