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靛玉红

靛玉红用途

Indirubin(Couroupitine B)是一具有抗炎症和抗癌活性的天然化合物。

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靛玉红名称

[ CAS 号 ]:
479-41-4

[ 中文名 ]:
靛玉红

[ 英文名 ]:
Indirubin

[中文别名 ]:

[英文别名 ]:

Indirubin
Indigo Red
2-ylidene)-1,3-dihydro
COUROUPITINE B
[2,3'-Biindolinylidene]-2',3-dione
MFCD00221745
INDIGOPURPURIN

靛玉红生物活性

[ 描述 ]:

Indirubin(Couroupitine B)是一具有抗炎症和抗癌活性的天然化合物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 生物碱

研究领域 >> 癌症

[参考文献]

[1]. Kim MH, et al. Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. J Ethnopharmacol. 2013 Jan 9;145(1):214-9.

[2]. Hsieh WL, et al. Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal keratinocytes. J Dermatol Sci. 2012 Aug;67(2):140-6.

[3]. Zhang X, et al. Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell. Int J Cancer. 2011 Nov 15;129(10):2502-11.

[4]. Alex D, et al. Indirubin shows anti-angiogenic activity in an in vivo zebrafish model and an in vitro HUVEC model. J Ethnopharmacol. 2010 Sep 15;131(2):242-7.

[相关活性小分子]

靛玉红物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
496.6±45.0 °C at 760 mmHg

[ 熔点 ]:
350 °C

[ 分子式 ]:
C₁₆H₁₀N₂O₂

[ 分子量 ]:
262.263

[ 闪点 ]:
207.0±28.9 °C

[ 精确质量 ]:
262.074219

[ PSA ]:
58.20000

[ LogP ]:
2.48

[ 外观性状 ]:
微红的-紫罗兰色粉末

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.709

[ 储存条件 ]:
0-10°C;避免加热

靛玉红MSDS

详细MSDS(安全技术说明书)

靛玉红毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU2995000

CHEMICAL NAME :: (delta(sup 2,3')-Biindoline)-2',3-dione

CAS REGISTRY NUMBER :: 479-41-4

BEILSTEIN REFERENCE NO. :: 0088279

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H10-N2-O2

MOLECULAR WEIGHT :: 262.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,24,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,266,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 36400 mg/kg/26W-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 12,75,1981

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靛玉红安全信息

[ 危害码 (欧洲) ]:
N

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S36/37

[ 海关编码 ]:
2933990090

靛玉红合成路线

详细合成路线

靛玉红上下游产品

靛玉红上游产品

靛玉红下游产品

靛玉红海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

靛玉红