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甲基丁二酸

甲基丁二酸用途

2-Methylsuccinic acid 是人体液中的一种正常代谢物,是乙基丙二酸脑病的主要生化指标。

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甲基丁二酸名称

[ CAS 号 ]:
498-21-5

[ 中文名 ]:
甲基丁二酸

[ 英文名 ]:
UNII:H1547KG7UZ

[中文别名 ]:

[英文别名 ]:

UNII:H1547KG7UZ
d-Methylsuccinic acid
2-methylbutanedioic acid
2-Methylsuccinic acid
Pyrotartaric Acid
METHYLSUCCINIC ACID
MFCD00002659
Butanedioic acid, 2-methyl-
EINECS 207-857-1
Methylbutanedioic acid

甲基丁二酸生物活性

[ 描述 ]:

2-Methylsuccinic acid 是人体液中的一种正常代谢物,是乙基丙二酸脑病的主要生化指标。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

2-甲基琥珀酸是人体液中的正常代谢物,是乙基丙二酸脑病的主要生化可测量特征[1]。潜在的生化缺陷涉及异亮氨酸分解代谢[2]。

[参考文献]

[1]. Grosso S, et al. Ethylmalonic encephalopathy: further clinical and neuroradiological characterization. J Neurol. 2002 Oct;249(10):1446-50.

[2]. Nowaczyk MJ, et al. Ethylmalonic and methylsuccinic aciduria in ethylmalonic encephalopathy arise from abnormal isoleucine metabolism. Metabolism. 1998 Jul;47(7):836-9.

[相关活性小分子]

甲基丁二酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
236.5±13.0 °C at 760 mmHg

[ 熔点 ]:
110-115 °C(lit.)

[ 分子式 ]:
C₅H₈O₄

[ 分子量 ]:
132.115

[ 闪点 ]:
111.1±16.3 °C

[ 精确质量 ]:
132.042252

[ PSA ]:
74.60000

[ LogP ]:
-0.24

[ 外观性状 ]:
白色至米色结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.474

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with bases, oxidizing agents, reducing agents.

甲基丁二酸MSDS

甲基丁二酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2917190090

甲基丁二酸合成路线

甲基丁二酸上下游产品

甲基丁二酸上游产品

甲基丁二酸下游产品

甲基丁二酸制备

1.以丁烯酸为原料，经以下步骤制得。将丁烯酸和乙醇与四氯化碳混合，添加硫酸，回流反应12h，回收乙醇和四氯化碳，并盐析得到巴豆酸乙酯。将巴豆酸乙酯、乙醇与氰化钠水溶液回流反应5h。再加入氢氧化钡溶液，经减压浓缩至粥状，冷却。加入硝酸，剧烈反应放出氰化氢气体。减压浓缩至干，用苯、乙醚提取后得粗品，最后用苯、水重结晶各一次，即得成品。

2. 烟草：BU，26。

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甲基丁二酸海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

甲基丁二酸文献

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

SPE-NMR metabolite sub-profiling of urine.

Anal. Bioanal. Chem 404(8) , 2349-61, (2012)

NMR-based metabolite profiling of urine is a fast and reproducible method for detection of numerous metabolites with diverse chemical properties. However, signal overlap in the (1)H NMR profiles of hu...

Concentrations of riboflavin and related organic acids in children with protein-energy malnutrition.

Am. J. Clin. Nutr. 71(4) , 978-86, (2000)

Riboflavin, flavin mononucleotide (FMN), and flavin adenine dinucleotide (FAD) concentrations have been little studied in cases of malnutrition.Our objective was to investigate the effects of malnutri...

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