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3-硝基丙酸

3-硝基丙酸用途

3-Nitropropanoic acid 是琥珀酸脱氢酶的不可逆抑制剂。

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3-硝基丙酸名称

[ CAS 号 ]:
504-88-1

[ 中文名 ]:
3-硝基丙酸

[ 英文名 ]:
3-Nitropropanoic acid

[中文别名 ]:

3-氮丙酸

[英文别名 ]:

Propanoic acid, 3-nitro- (9CI)
Propanoic acid,3-nitro
Propanoic acid, 3-nitro-
Hiptagenic acid
3-Nitropropionate
Propionic acid,3-nitro
Bovinocidin
3-nitro propionic acid
RN 1 dihydrochloride
β-Nitropropionic acid

3-硝基丙酸生物活性

[ 描述 ]:

3-Nitropropanoic acid 是琥珀酸脱氢酶的不可逆抑制剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[ 靶点 ]

succinate dehydrogenase[1]

[参考文献]

[1]. Huang LS, et al. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J Biol Chem. 2006 Mar 3;281(9):5965-72.

[相关活性小分子]

3-硝基丙酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
303.0±25.0 °C at 760 mmHg

[ 熔点 ]:
68-70ºC(lit.)

[ 分子式 ]:
C₃H₅NO₄

[ 分子量 ]:
119.076

[ 闪点 ]:
148.4±11.6 °C

[ 精确质量 ]:
119.021858

[ PSA ]:
83.12000

[ LogP ]:
-0.08

[ 外观性状 ]:
金色结晶固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.463

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, bases, reducing agents.

[ 水溶解性 ]:
alcohol: 100 mg/mL, may be light yellow

3-硝基丙酸MSDS

详细MSDS(安全技术说明书)

3-硝基丙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UF6220000

CHEMICAL NAME :: Propionic acid, 3-nitro-

CAS REGISTRY NUMBER :: 504-88-1

BEILSTEIN REFERENCE NO. :: 1759889

LAST UPDATED :: 199706

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C3-H5-N-O4

MOLECULAR WEIGHT :: 119.09

WISWESSER LINE NOTATION :: WN2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 67 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 68100 ug/kg

TOXIC EFFECTS :: Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1870 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 50 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 196,61,1988

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3-硝基丙酸安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
Missing Phrase - N15.00950417

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
25-36/37/38

[ 安全声明 (欧洲) ]:
26-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
UF6220000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2915900090

3-硝基丙酸合成路线

详细合成路线

3-硝基丙酸上下游产品

3-硝基丙酸上游产品

3-硝基丙酸下游产品

3-硝基丙酸海关

[ 海关编码 ]: 2915900090

[ 中文概述 ]:
2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

3-硝基丙酸文献

Suppression of Cpn10 increases mitochondrial fission and dysfunction in neuroblastoma cells.

PLoS ONE 9(11) , e112130, (2014)

To date, several regulatory proteins involved in mitochondrial dynamics have been identified. However, the precise mechanism coordinating these complex processes remains unclear. Mitochondrial chapero...

Quantification of nitropropanoyl glucosides in karaka nuts before and after treatment.

Food Chem. 175 , 543-8, (2015)

A high performance liquid chromatography (HPLC) method was developed to assay nitropropanoyl glucosides in the nuts of karaka (Corynocarpus laevigatus) a traditional food of New Zealand Māori. Levels ...

Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway.

Neuroscience 227 , 134-43, (2012)

Nuclear factor-erythroid 2-related factor-2 (Nrf2) mediated regulation of cellular antioxidant production and the anti-inflammatory mechanism play an important role in neuroprotection against neurodeg...

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